This study focuses on neuroimaging methods such as structural magnetic resonance imaging (sMRI) and fluorodeoxyglucose positron emission tomography (FDG-PET) have been used to diagnose and categorize AD
This study investigates the relationship between antidiabetic drugs and Alzheimer’s disease (AD) in a population-based sample.
This review discusses the impact of Apolipoprotein-E4 (ApoE4) on cognitive performance in targeted-replacement human ApoE knock-in mice, finding that ApoE4 mice exhibit significant cognitive deficits compared to ApoE3 mice in various cognitive tests, indicating an intrinsic vulnerability in ApoE4 mice that may be exacerbated in the context of neurodegenerative diseases.
Indigenous Peoples face disproportionate risks from climate change while being key to planetary health and climate resilience due to their traditional ecological knowledge. This manuscript provides Indigenous perspectives on climate justice, exploring the intersection of health, sovereignty, and ancestral practices, and discusses opportunities for decolonizing relationships to place, highlighting a case of rematriation and healing at Bdóte, the place of genesis for Dakota Peoples, also known as Minneapolis and Saint Paul, MN.
To optimize the delivery of culturally safe care, health systems need to rebuild their relationship with Indigenous peoples.
The results of this study emphasize the importance of considering lifestyle aspects like sleep, physical activity, and social support when creating effective strategies to prevent depression in university students.
This study aimed to examine relationships among eating frequency, timing and time window, and cognitive performance and novel Alzheimer disease (AD) biomarkers in cognitively healthy and mildly cognitively impaired middle-aged and older adults. It concluded that an eating pattern characterized by less frequent eating and/or by earlier times is present in individuals with worse cognitive performance. The results shed light on the relevance of temporal eating patterns as potential early markers of behavioral or metabolic changes related to AD pathology.
This article provides evidence that disruption of the intestinal mucosal barrier contributes to sarcopenia and functional dependence in patients with AD. RE may be an effective therapy to strengthen the intestinal mucosal barrier, reduce sarcopenia, and improve functional performance in patients with AD.
This review provides a comprehensive overview of both conventional and novel therapeutic strategies for Alzheimer's disease (AD), highlighting traditional Acetylcholinesterase (AChE) inhibition and emerging approaches such as Butyrylcholinesterase (BChE) inhibition, Tau Protein inhibitors, and COX-2 inhibition, while also exploring the roles of endocannabinoids, cholesterol-lowering drugs, and microRNA, alongside novel research tools and current clinical trials, to offer a consolidated resource for advancing AD treatment and research.
