Humans harbor complex communities of microbes, predominantly bacteria, that live symbiotically within the colon. There are several factors that influence the trajectory of gut microbiota in infants such as birth term, mode of delivery, and dietary habits.
Elsevier, A Review on Diverse Neurological Disorders: Pathophysiology, Molecular Mechanisms, and Therapeutics, Volume , 1 January 2024
Due to the aging population, both Alzheimer's disease (AD) and Parkinson's disease (PD) are degenerative brain disorders that are now recognized as important public health issues.
This study indicates that among people with higher levels of disability, engaging in physical activity is linked to more effective stress coping through enhanced self-efficacy. However, this effect was not observed among people with low levels of disability.
This content aligns with Goal 3: Good Health by describing cronic infection due to hepatitis C virus (HCV) that is among the most common etiologic factors of vasculitis in humans.
This study identifies research trends and hotspots on the comorbidity between periodontitis and neurodegenerative diseases, incl. Alzheimer's.
The objective of this study was to assess the neuropsychological characteristics of individuals with early-onset Alzheimer's disease (EOAD), late-onset Alzheimer's disease (LOAD), and very-late-onset Alzheimer's disease (VLOAD). The findings indicate notable neuropsychological variations across different age groups, demonstrating a progressive decline in cognitive function with age rather than distinct clinical presentations.
The authors put forward a mathematical model for examining the impact of water, sanitation and hygiene (WASH) services on reducing the transmission of waterborne diseases such as enteric diarrheal disease (EDD). It is found that wastewater and sewage treatment (WST) control has the most significant impact in terms of WASH interventions employed. The findings have could have very important public health potential and tie in strongly with the goals of SDG 6.
This article supports SDG 3 as understanding the role of HCV core proteins in viral diseases is crucial to elucidating disease mechanisms and identifying potential drug targets. However, purification challenges may hinder the comprehensive elucidation of the structure and biochemical properties of HCV core proteins.
In Alzheimer's disease research, cerebrospinal fluid (CSF) biomarkers Amyloid beta (Aβ), Tau, and pTau are well-validated, and this study demonstrates that a Z-score based harmonization approach can effectively standardize CSF and amyloid imaging data across multiple cohorts, providing consistent biomarker cut-offs and comparable GWAS results to traditional methods, without introducing spurious findings.
This article discusses the manifestation of apathy-like behaviors in Alzheimer's disease (AD) and frontotemporal dementia (FTD) mouse models through the assessment of nest-building behavior, highlighting differences in nesting proficiency and anhedonia between tau transgenic mice lines, suggesting apathy-like phenotypes in the context of neurodegenerative diseases.
