Despite significant investment, effective treatments for Alzheimer's disease (AD) have been elusive, necessitating improved quality and reproducibility of foundational laboratory evidence; to address this, AD-SOLES, an integrated workflow of automated tools and a publicly accessible interactive dashboard, has been developed to collect, curate, and visualize in vivo experimental evidence, enhancing evidence synthesis, tracking reporting quality, and aiding researchers in locating relevant data.
Nurse practitioners and other health care providers can play a crucial role in implementing chronic disease management strategies and educating patients who are at risk for AD among African Americans and Hispanics.
The study demonstrates that the peptide PHDP5, which inhibits dynamin-MT interaction, can rescue impaired endocytosis and synaptic transmission caused by tau in presynaptic terminals. When administered intranasally to Alzheimer's disease (AD) model mice, PHDP5 significantly improved learning and memory, suggesting its potential as a candidate for human AD therapy.
In this study, the authors estimate the causal effect of air pollution on eye and ear health. They find that eye or ear disease possibility rises 1.48% for a 10 μg/m3 increase in four-week average PM2.5 concentration. The impacts can last about 28 weeks and will be insignificant afterward.
The article systematically reviews research linking climate change to food systems, nutrition, and health (FSNH) from 2018-2023. It identifies key research gaps and presents an Evidence and Gap Map (EGM) to visualize the current landscape. Most studies focus on climate impacts on crop and livestock production, while fewer address nutrition-related health and postharvest processes. Addressing these gap is critical for developing effective climate adaptation and mitigation strategies that promote both human and planetary health.
The article discusses the impact of malaria on tribal and indigenous populations in India. The article emphasizes the need to prioritize tribal-dominated, high-endemic regions with concerted efforts and holistic socio-economic development to achieve malaria elimination in India.
This special issue focuses on Women's cardiovascular health, and this study looks at midlife women who have metabolic syndrome.
The collective evidence shows that CEM as a work-up tool in women recalled from breast cancer screening is more efficient in terms of resources needed, and it detects more occult lesions than the control group.
This study show receiving a BP improves childbirth experiences in women, increases women's participation in the labor process because of increased information and awareness, and strengthens their self-control and self-management.
Multiple HPV infections aggravate SILs compared with single infection. The development and promotion of HPV vaccines should be carried out based on its regional difference.
