This article discusses the potential therapeutic strategy of enhancing mitophagy through rapamycin treatment to alleviate cognitive impairment in Alzheimer's disease by improving mitochondrial dysfunction and neuronal loss, suggesting a novel mechanism for the neuroprotective effects of rapamycin in AD.
This review discusses the multifaceted physiological functions of cholecystokinin (CCK), its potential neuroprotective effects in Alzheimer’s and Parkinson’s diseases, and its therapeutic implications, including its impact on memory, neurotransmitters, and neuroprotection mechanisms.
This study demonstrates that electroacupuncture (EA) improves learning and memory in the 5xFAD mouse model of Alzheimer's disease, likely by enhancing functional connectivity between the hippocampus and neocortex and reducing amyloid-β protein expression and deposition. These findings suggest that EA may positively impact resting-state brain activity and connectivity, contributing to cognitive and motor function improvements in AD.
Despite diagnostic challenges in differentiating lvPPA and nfvPPA, particularly in advanced cases, this study reveals divergent clinical courses and highlights the importance of assessing emotion processing capacity in dementia diagnosis and monitoring. Utilizing spatiotemporal LME modelling, the research provides valuable insights into the dynamic changes in brain atrophy and behavior, underscoring the need for ongoing evaluation of clinical requirements for patients and families over the disease course.
2026's World Leprosy Day: A Unified Call for Dignity and Healing
Celebration and Recognition
World Leprosy Day is commemorated each year on the final Sunday of January, promoting worldwide unity in the battle against leprosy. On January 26th, 2026, this day will occur. In India, January 30th is an important event that is observed annually to pay tribute to Mahatma Gandhi's death anniversary. Gandhi was a strong supporter of the rights and respect for individuals stricken with leprosy.
This study investigated antiviral effects in a real-world cohort of non-cirrhotic CHB patients with varying degrees of HS, assessed by transient elastography (TE) with controlled attenuation parameter (CAP).
The present article reviews the role of necroptosis, as a novel cell death pathway, in Aluminium-induced Alzheimer’s disease models in vitro and in vivo.
This study aims to develop novel prognostic models based on the dynamic changes in variables to predict the short-term mortality of HBV-associated ACLF (HBV-ACL)
Systematic review on Global outbreaks of foodborne hepatitis
This Article supports SDG 3 by arguing that people under community correction supervision (probation or parole) are a large population of individuals at risk of viral hepatitis, to whom little attention has thus far been paid. Targeting hepatitis testing and treatment services at this population would be feasible and effective in reducing hepatitis incidence.
