Neuron, Volume 102, 3 April 2019,
Perinatal depression (PND) is a heterogeneous disorder with differences in timing of onset of depression, which influences symptomology, severity, and treatment efficacy. Researchers must embrace the heterogeneity to bring fruition to a precision medicine approach for women in reproductive mental health care. Galea and Frokjaer discuss the heterogeneity of perinatal depression based on timing onset, which influences symptoms and has implications for etiology and treatment efficacy. The clinical and research community can exploit this heterogeneity to uncover precision treatment strategies.
Animal; Animals; Antisocial Behavior; Anxiety; Brain Cortex; Brexanolone; Compulsion; Compulsive Behavior; Depression, Postpartum; Depressive Disorder, Major; Disease Model; Disease Models, Animal; Dorsal Raphe Nucleus; Drug Effect; Drug Efficacy; Estriol; Female; Hippocampus; Human; Humans; Hydrocortisone; Major Depression; Metabolism; Nonhuman; Obsession; Obsessive Behavior; Pathophysiology; Perinatal Depression; Personalized Medicine; Postnatal Depression; Precision Medicine; Pregnancy; Pregnancy Complication; Pregnancy Complications; Priority Journal; Progesterone; Protein Expression; Psychological Well-being; Psychology; Puerperium; Risk Factor; Serotonin Transporter; Serotonin Uptake Inhibitor; Short Survey; Suicide; Global