The article provides a comprehensive review of the role of semaphorin 3A (Sema3A) in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases. It discusses the expression patterns and mechanisms of action of Sema3A in various age-related disorders, including its involvement in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity.
 Empirical evidence on cognitive function and its association with demographic, socioeconomic, health and behavioural factors among older adults in rural Bangladesh.
The article discusses the role of gut dysbiosis, bacterial amyloids, and metabolic diseases in the development and progression of Alzheimer's disease (AD). It highlights the bidirectional relationship between the gut microbiome, inflammation, and metabolic disorders, and how these interconnected pathways contribute to neurodegeneration. The review explores potential therapeutic strategies targeting the gut-brain-metabolic axis to mitigate AD progression.
This systematic review examined the relationship between cognition and motor speech production in healthy older adults and those with mild cognitive impairment, analyzing 22 studies with 747 participants. Findings suggest that cognitive functions, particularly attention and executive abilities, are linked to motor speech performance, though evidence quality varies and gaps remain.

The article examines the relationship between falls, chronic pain, and frailty among middle-aged and older adults in Yunnan Province, China, with a focus on ethnic minority populations.

Agriculture faces the increasing demands of a growing global population amid simultaneous challenges to soils from climate change and human-induced contamination.
Elsevier,

 

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Despite global progress, maternal mortality remains high, especially in sub-Saharan Africa, highlighting the urgent need for strong leadership, increased investment in well-trained midwives, and equitable, culturally sensitive maternity care to achieve the Sustainable Development Goal of reducing maternal deaths to less than 70 per 100,000 live births by 2030.

This study identified over 2,000 proteins in cerebrospinal fluid that change at different stages before Alzheimer's symptoms appear, revealing key biological processes involved in the disease. Using machine learning, the researchers developed highly accurate models to predict Alzheimer's biomarker status, clinical diagnosis, and future disease progression.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by providing an overview of the cholinergic hypothesis of Alzheimer's Disease and potential innovations in cholinergic therapies.

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