This podcast discusses the relevance of lipid oxidation in brain activity, how work in redox proteomics helps us to understand the role of specific proteins in the development of Alzheimer's pathology, why metabolic disorders have such a major risk factor for the development of dementia. how down syndrome is a model of Alzheimer's and Dr. Butterfield's thoughts on future antioxidant strategies in the prevention and treatment of Alzheimer's & new therapeutic approaches. Plus advice for young people pursuing science and medicine as a career.
This Article supports SDG 3 by presenting a conceptual framework and a method to estimate cost-effectiveness thresholds for 174 countries, using public and widely available data on country-specific health expenditures and health outcomes; these findings can inform policy makers on the thresholds to consider when deciding on the allocation of health resources.
This systematic literature review on on-site sanitation fecal sludge management practices directly informs Sustainable Development Goal 6 (SDG 6) by identifying best practices for safe sanitation, reducing pollution, and protecting water resources.
This Article supports SDG 3 by showing that an HCV testing (point-of-care) and treatment programme implemented in users of a supervised drug cosumption service in Canada was beneficial, with a large degree of positive testing, testing acceptance, and treatment engagement. The study suggests that on-site point of care testing and treatment for HCV in supervised consumption services is effective in reaching this population
This Article supports SDG 3 by using modelling to estimate the impact of immigration on hepatitis B prevalence in the USA, in order to more accurately assess the hepatitis B burden, which might not be accurately measured by national serosurveys. The study found a significantly higher burden of hepatitis B (1.8 million cases), significantly higher than that found in national serosurveys.
This Article supports SDG 3 by assessing the incidence of HIV and HCV infection among people who inject drugs, a population at higher risk of these infections. In this systematic review, HCV estimates came from studies in 24 countries. Pooled HCV incidence was 12.1 per 100 person-years; data for both infections were scarce, suggesting increased efforts are needed to keep track of these infections in this population.
This Article supports SDG 3 by estimating the burden of low back pain, which continues to be the leading cause of disability worldwide. The study predicts that low back pain prevalence will continue to increase, from 619 million people in 2020 to 843 million in 2050. Two-fifths of the burden are due to modifiable risk factors, and a quarter of years lived with disability are attributable to occupational ergonomic factors.
