This Article supports SDGs 3 and 6 by demonstrating that polio environmental surveillance by testing wastewater samples is a valuable tool for tracking the distribution of polio and non-polio enteroviruses, and could be instrumental for global poliovirus elimination efforts.
Young adult hematopoietic cell transplantation (HCT) survivors have impaired health-related quality of life (HRQOL) compared with older adult survivors. Adolescents and YAs are at a developmental stage marked by rapid changes in cognitive, social, and emotional growth and historically have experienced a gap in services relating to their psychosocial needs. Findings confirm the hypothesis that self-efficacy would be pivotal to higher levels of mental function and lower distress.
The lung is a crucial immune organ continuously exposed to the external environment. Genetic defects that impair immune function, called inborn errors of immunity (IEI), often have lung disease as the initial and/or primary manifestation. Common types of lung disease seen in IEI include infectious complications and a diverse group of diffuse interstitial lung diseases.
Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant disorder characterized by progressive muscle weakness. Adenine nucleotide translocator 1 (ANT1), the only 4q35 gene involved in mitochondrial function, is strongly expressed in FSHD skeletal muscle biopsies. However, its role in FSHD is unclear. In this study, we evaluated ANT1 overexpression effects in primary myoblasts from healthy controls and during Xenopus laevis organogenesis. We also compared ANT1 overexpression effects with the phenotype of FSHD muscle cells and biopsies.
This Article supports SDG 3 and 5 by highlighting a need for greater involvement of in-country authors on research examining a wider range of gendered COVID-19 impacts, as well as increased representation of diverse topics and publications related to COVID-19 and women's well-being focused on lower income countries.
This Study supports SDG 5 and 3 by examining the role of improved women's agency on the pathway from the intervention to nutritional impacts.
![Overview of brain [64Cu]-ATSM retention and mitochondrial abnormalities in cells from Huntington's disease carriers, at premanifest and manifest disease stages, and in presymptomatic YAC128 mice.](https://sdgresources.relx.com/sites/default/files/styles/sus_content_listing_image/public/mitochondrial_and_redox_modifications.jpg?itok=PGIl7bso "Overview of brain [64Cu]-ATSM retention and mitochondrial abnormalities in cells from Huntington's disease carriers, at premanifest and manifest disease stages, and in presymptomatic YAC128 mice.")
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD). However, whether these changes occur in early stages of the disease and can be detected in vivo is still unclear. In this article, the authors analysed changes in mitochondrial function and production of reactive oxygen species (ROS) at early stages and with disease progression.
This Article supports SDG 3 by estimating the impacts of the centralisation of specialist cancer services, focusing on travel time, equity of access, outcomes, and hospital workload. Using rectal cancer surgery centres as an example the authors found increases in travel times but reductions in readmission rates.
The article suggests actions to reduce the negative effect of pandemics on the healthcare workers in future situations, based on lessons learnt from COVID19.
This Article supports SDGs 3 and 16 by measuring the rate of heart transplantation among Black and White waitlist candidates. The findings suggest that transplantation rates, as well as the rate of delisting for death or clinical deterioration, has worsened for Black candidates compared with White candidates, and that the causes for this disparity require further study.
