Ensure healthy lives and promote well-being for all at all ages
This Article supports Sustainable Development Goal 3 by calculating the proportion of dementia in Australia attributable to 11 potentially modifiable risk factors. They found that 38% of dementia was attributable to these risk factors (increasing to 41% when a 12th risk factor, traumatic brain injury, was added). The authors note that these findings could help to guide culturally specific dementia risk reduction programmes.
The role of estrogen and ferroptosis in Alzheimer's disease is known. Ginseng has estrogen-like effects as well as a regulatory role in Alzheimer's disease and iron metabolism and this paper discusses for the frist time the link between ginseng, ferroptosis, and Alzheimer's disease.
This article underscores the need to screen early for balance issues and fall risk in patients with Alzheimer's, as these patients are more prone to falls. The end goal is to promote earlier screening so as to better improve their quality of life.
Elsevier,
Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, Volume 271, September 2023
OKA is a potent neurotoxin and has a profound effect on cognitive dysfunction in Zebrafish. 4D and 10D OKA treated zebrafish show significant changes in gene expressions related to neuroinflammation. OKA exposed zebrafish display a substantial number of proteins that are involved in contributing to AD pathology. OKA-induced AD in zebrafish model can be used as a screening tool to explore further underlying possible mechanisms.
This Article supports Sustainable Development Goal 3 by estimating the prevalence of dementia in people aged 60 years and older in Bangladesh, finding an overall prevalence of 8%, and identifying positive associations between dementia prevalence and female sex, advanced age, and lower education levels.
This Article supports Sustainable Development Goal 3 by showing that although there was an increase in prescribing of antipsychotics to people with dementia during the COVID-19 pandemic, this increase was not responsible for the large increase in all-cause and stroke mortality in this population.
This Article supports Sustainable Development Goal 3 by advancing our understanding of the possible role of active immunotherapy against amyloid-β in individuals with mild Alzheimer's disease; the findings of this phase 2a study support the continued clinical development of UB-311 as an active immunotherapy for Alzheimer's disease.
This Article supports Sustainable Development Goal 3 by identifying an independent relationship between anxiety and subsequent cognitive progression in older people without dementia; these findings suggest that treating anxiety and targeting mitochondrial dysfunction may be effective in preventing dementia.
Using brain tissue from donors with Alzheimer's disease, Anderson et al. identify new links between gene regulation and disease. These regulators could represent future clinical targets or disease markers for Alzheimer's diagnosis and treatment.
In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
