Background: In patients with cystic fibrosis (CF), thoracic morphology and its role in respiratory function is conditioned by anthropometric factors, as well as by pathological changes. While the lungs are continuously monitored, examinations of potential thoracic cage adaptations to the disease are rare. Hence, the aim of this study was to investigate thoracic configuration, and its correlation to spirometry measures over time. Methods: In total, 344 high-resolution computed tomography (HRCT) examinations from 90 patients were assessed and analysed. Those results were subsequently related to spirometry measurements performed within the same period. Results: The cohort displayed no homogenous change in thoracic configuration over time, and correlation between thoracic area and spirometry variables could not be supported statistically. Conclusions: Although the current study included a larger cohort of patients with CF compared to previous studies on thoracic morphology, no patient group-specific changes in thoracic configuration were revealed. Furthermore, no correlations between structural findings and functional respiratory measurements were found.
This article ties to SDG 3. Analyzing relations among neuronal, endocrine, immune, and biochemical signatures of trauma and internalizing and externalizing behaviors, including the role of personality traits in shaping these conducts, this review highlights that the marked effects of traumatic experience on the brain/body involve changes at nearly every level of analysis, from brain structure, function and connectivity to endocrine and immune systems, from gene expression (including in the gut) to the development of personality.
This Article supports SDGs 3 and 5, focusing on assessing cardiovascular mortality risk in women with hypertensive disorders of pregnancy, compared with normal blood pressure during pregnancy.
This Personal View supports SDGs 3 and 16 by presenting a case study using Indigenist health humanities to offer a way to understand planetary health. The authors indicate that embedding Indigenous knowledge and voices into planetary health education is important as part of decolonising learning in health professional education.
TK2d is an ultrarare autosomal recessive mitochondrial DNA depletion syndrome. Nucleoside therapy improves or stabilizes disease across key outcomes including survival, ambulation, and requirement for mechanical ventilation. However, little is known about the effects of nucleoside therapy treatment of TK2d from the patient's perspective. This study sought to address this knowledge gap.
This Article supports SDGs 3, 5 and 9 by outlining how, in the current legal landscape, to reduce the collection and documentation of reproductive health information in nuclear medicine in light of the SCOTUS decision on Dobbs v Jackson Women's Health Organization that overturned a 49-year-old federal recognition of abortion rights.
This article advances SDG goals 5 and 10 by examining barriers that deter Black patients from enrolling in clinical trails and how those can be overcome for the sake of improving diverse patient outcomes.
This article ties to SDG 3. This review highlights evidence that Maternal Separation (MS) interferes with neural development to permanently alter bed nucleus of the stria terminalis (BNST) circuitry, which may account for a variety of behavioral deficits seen following early life stress.
This Article supports SDGs 3, 5, 10 and 16 by assessing changes in stillbirth rates overall and for Black and White women, finding that there was a substantial racial disparity and suggesting that targeted health and social policies are needed to address this issue.
This article ties to SDG 3. A systematic review and meta-analysis was conducted evaluating stepped care prevention (i.e., targeting those with recent trauma exposure at risk of developing PTSD) and treatment approaches for adults and adolescents/children with PTSD.
