Gender-neutral mental health research is sex and gender biased

Elsevier, The Lancet Psychiatry, Volume 4 No 1 January 2017
Louise M Howard, Anna M Ehrlich, Freya Gamlen, Sian Oram

Few would disagree that sex is of relevance in understanding and treating mental disorders, but there seems to be less consensus on the extent to which researchers should consider sex and gender in study design, analysis, and interpretation. The Institute of Medicine defines sex as “the classification of living things, generally as male or female according to their reproductive organs and functions assigned by chromosomal complement”. Gender is defined as “a person's self-representation as male or female, or how that person is responded to by social institutions based on the individual's gender presentation.