This Article supports Sustainable Development Goal 3 by highlighting differential effects of sleep disturbances on resting-state neural activity in patients on the Alzheimer's disease spectrum relative to healthy adults, suggesting a key role of sleep disturbances in the neurophysiological changes seen in Alzheimer's disease, with implications for basic research and clinical intervention.
The authors explore automatic and early detection methods for Alzheimer’s disease (AD) using deep learning techniques in order to improve the speed and accessibility of current testing methods. They propose a deep transfer learning model as a new approach for accurately detecting categories of Alzheimer's disease. The research serves SDG 3's aim in highlighing and seeking better treatment for AD, an increasingly serious global public health issue.
This is a Personal View discussing socioeconomic risk factors for dementia in women in Latin American Countries, with emphasis on gender roles and expectations that can infleuence the onset and prevalence of dementia
In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.
SCFA contribute to the glutamate-glutamine shuttle by acting on glutamine synthetase. Long-term SCFA diet alleviates cognitive and spatial memory defeat in APP/PS1 mice. Long-term SCFA diet reduces Aβ deposition and abnormal phosphorylation of tau. SCFA promote astrocyte-neuron metabolic coupling to reduce oxidative damage.
To mark the 50th Anniversary of World Environment Day on 5 June 2023, Elsevier proudly presents a curated list of publicly available journal articles and book chapters in support of this year's theme “Solutions to Plastics Pollution”. Please share and download.
This content supports the SDG Goal 3: Good health and well-being by providing a background understanding and framework to aid in the prevention, identification, and control of infectious diseases in disaster zones.
Talks about the welfare of cattle in the beef industry.
The authors of this paper developed and tested a culturally appropriate food picture-sort frequency tool that is feasible and acceptable to both Navajo children and adults. This tool and its indices have the potential to measure the change for school-based intervention studies among the Navajo Nation because of its cultural appropriateness, ease of administration and low burden, and the convergent validity and reliability of its indices.
This Article supports SDG 3 by assessing the cost-effectiveness of the "Birthing in Our Community" service in reducing preterm births in Australian First Nations families compared to standard care.
