This chapter aligns with the SDG goal 3 of good health and wellbeing by examining the properties of the enzyme, hepatitis C NS2/3 protease, with special emphasis on the catalytic components of its active site, and the mechanism by which it hydrolyzes peptide bonds.
Animal models are used with increasing numbers in the late LO phase and particularly in the candidate selection phase for pharmacokinetic/pharmacodynamic (PK/PD) and efficacy, and then also used in regulatory required safety studies. Therefore, there are opportunities throughout the drug discovery process to incorporate more translationally predictive cellular models, or CIVMs, to both reduce animal use aligned to our 3Rs commitment (replacement, reduction, and refinement) and provide data that better translate to the clinic, which ultimately results in better medicines for patients.
Elsevier,
How Sex and Gender Impact Clinical Practice, An Evidence-Based Guide to Patient Care, 2021, Pages 277-287
This book chapter advances SDGs 3 and 16 by examining three issues that are considered important public health issues as well as common patient problems—intimate partner violence, access to healthcare, and immunization—with a focus on sex and gender based medicine.
Elsevier,
Food Fraud, A Global Threat With Public Health and Economic Consequences, 2021, Pages 23-43
This book chapter addresses SDGs 3 and 10 by explaining US and EU regulatory requirements, Global Food Safety Initiative requirements, and reviews food fraud vulnerabiility.
Background: Research has revealed that survivors of childhood sexual abuse (CSA) have elevated sexual dysfunction and distress.
This book chapter advances SDGs 3 and 17 by providing an overview of the characteristic features of neurodegenerative diseases, including AD and how to assess them to validate or to reject the suspected diagnosis.
Background: Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR).
Elsevier,
Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases, 2021, Pages 41-55
This chapter aligns with the SDG goal 3 of good health and wellbeing by examining all possible hepatoprotective activities of natural products and plant extracts that lessen hepatitis C.
This chapter focuses on genetically modified crops that can aid farmers in increasing crop resilience and productivity. While their safety and ethics have raised concern, these promising technologies offer hope for the improvement of food security for global populations, especially those in under-developed or developing countries.
Background: Coronovirus disease 2019 (COVID-19) first broke out in Wuhan, Hubei Province, China, in 2019, and now it spreads in more than 100 countries around the world.
