Global

Elsevier,

hLife, Volume 3, Issue 1, January 2025, Pages 5-20

The review explores the role of gut microbiota in high-altitude adaptation, highlighting how microbial alterations impact host physiology and metabolism under hypoxic conditions and discussing potential strategies for enhancing acclimatization through microbiota modulation.

Front cover image of 50:50 by 2030 report

IBA 50:50 by 2030 Progress Report was released by the IBA Legal Policy & Research Unit (LPRU) in collaboration with the LexisNexis Rule of Foundation

The article discusses the discovery of the A673V mutation in the amyloid precursor protein (APP) gene, which is associated with the familial form of Alzheimer's disease (AD) in a homozygous state. It provides an in-depth review of the molecular insights and therapeutic potential of the A?A2V peptide, including the development of a neuroprotective peptide A?1-6A2V(D) that inhibits amyloid-? aggregation and toxicity in preclinical models of AD and primary tauopathies

The authors propose a multi-attribute group decision-making (MAGDM) approach to evaluate and select digital voting tools that facilitate public participation in urban transport decision-making.

When women who are taking thyroid hormones become pregnant, they are often requested to take double the dosage immediately. Read the study to learn proper dosage and timing for pregnant women taking thyroid hormones.

 This study evaluated the ability of dental students to screen for osteoporosis on PRs.

This article highlights the efforts and successes of the Chemistry Women Mentorship Network (ChemWMN) in the US, a structured mentorship network open to all woman-identifying individuals in chemistry interested in advancing in the academic landscape.

This review synthesizes the latest evidence on the epidemiology, screening, and treatment of osteoporosis in men, with a focus on genetic, environmental, and epidemiological disparities between Eastern and Western populations.

This study investigates variations in the ice-flow speed of the Shirase Glacier ice tongue in East Antarctica from July 2018 to December 2021 using Sentinel-1 radar imagery. It identifies significant slowdown events linked to icebergs grounding on the seafloor, revealing that the ice tongue provides limited support to the grounding line, which has broader implications for understanding glacier dynamics and the potential consequences of ice loss in the context of climate change.
The article describes the development of a self-regulated multi-functional nano-modulator (siR/PIO@RP) that can intelligently navigate to the damaged blood-brain barrier and release therapeutic cargoes for synergetic Alzheimer's disease (AD) therapy. The nano-modulator is capable of reducing cerebral amyloid-β load, relieving neuroinflammation, and alleviating the dysfunction of the neurovascular unit, providing proof of concept that normalizing the neurovascular unit holds promise as a means of alleviating AD symptoms.

Pages