PLCγ2 is genetically linked to Alzheimer’s disease (AD), but it is unclear how PLCγ2 contributes to pathology. Tsai et al. demonstrate that AD-associated PLCG2 variants bidirectionally orchestrate microglial responses to plaques and impact neural function in an AD mouse model. This positions PLCγ2 as a key microglial signaling node and shows that targeting PLCγ2 could have therapeutic benefits in AD.
The role of estrogen and ferroptosis in Alzheimer's disease is known. Ginseng has estrogen-like effects as well as a regulatory role in Alzheimer's disease and iron metabolism and this paper discusses for the frist time the link between ginseng, ferroptosis, and Alzheimer's disease.
This Article supports Sustainable Development Goal 3 by calculating the proportion of dementia in Australia attributable to 11 potentially modifiable risk factors. They found that 38% of dementia was attributable to these risk factors (increasing to 41% when a 12th risk factor, traumatic brain injury, was added). The authors note that these findings could help to guide culturally specific dementia risk reduction programmes.
This Comment article supports SDG 3, 6, and 16 by highlighting the structural and commercial determinants of water crises and their effects on health, and calls for international cooperation and solidarity to address power asymmetry, inequalities, and unaffordable access to water, putting human rights at the core of the water agenda.
This Comment article supports SDG 3, 6, and 16 by referencing the damage to crucial water and sanitation infrastructure due to the armed conflict in Sudan, thus increasing the likelihood of diarrhoeal disease.
This Viewpoint supports SDG 3 and 10 by describing the health effects of settler colonial erasure and racial capitalist exploitation, arguing that widespread epistemic and material injustice, long noted by marginalised communities, is more apparent and challengeable with the consistent application of these two frameworks.
This Comment article supports SDG 3 and 10 by calling on all countries to urgently prioritise strengthening resilient and equitable health systems to achieve universal health coverage, framing universal health coverage as a matter of health, rights, and justice, as well as a key enabler of human security.
Hepatitis A virus-cellular receptor 2 (HAVCR2) mutation can be detected in hemophagocytic lymphohistiocytosis (HLH), which is associated with good prognosis.
This article supports SDG 3 by improving diagnostic capabilities for hepatitis E virus in blood donors.
This study contributes to SDG 3 by addressing safety improvements in hepatitis B treatment regimens.
