This article investigates the potential therapeutic effects of glutamic-oxaloacetic transaminase (GOT) in Alzheimer's disease (AD) by reducing glutamate concentrations in the hippocampi of mice, leading to improved neurological function, reduced β-amyloid protein levels, enhanced cognitive performance, increased neuron count and synaptic density, and altered protein expression, suggesting a promising treatment approach for early-stage AD.
This Article supports Sustainable Development Goal 3 by estimating the incidence and risk factors for vascular cognitive symptoms among first-ever stroke survivors in China, and shows an association of post-stroke cognitive impairment with age, education, and region (western China had higher rates of post-stroke cognitive impairment relative to other regions).
This Viewpoint supports Sustainable Development Goal 3 by discussing the effects of the FDA's approval of aducanumab, a treatment for early-stage Alzheimer's disease, despite its limited clinical benefit, as well as the decision of the Centers for Medicare and Medicaid Services to restrict coverage to individuals enrolled in clinical trials. The authors note that these decisions have led to a confusing landscape for patients with Alzheimer's disease.
The current review on atmospheric M/NPs is therefore focusing on sampling, sample preparation and identification methods. The approach will enable knowledge gaps to be identified, and recommendations to be made to support standardized and comparable future research
This review artcile, with contributionsform allover the world, describes various approaches to convert plastic wastes into new products known as an efficient way to manage them and to enhance the sustainability of the environment.
The introduction of long-acting injectable pre-exposure prophylaxis adds to the choice of HIV-prevention options; this study assesses the potential impact of roll-out in the refion with the highest HIV burden.
Human immunodeficiency virus and Simian immunodeficiency (SIV) are highly immune evasive viruses with few vulnerabilities. Cytomegalovirus vector-programmed MHC-E-restricted CD8+ T cells can mediate complete replication arrest of primary SIV infection with subsequent viral clearance; this approach may be promising for putative vaccines or immuno-therapeutics against HIV.
Good paper on how electroencephalography monitoring is being used as a method to diagnose Alzheimer's.
As the primary public health strategy for controlling the 2022 Mpox outbreak, it is critical to evaluate the impact of Mpox vaccination campaigns for transgender people and gay, bisexual and other men who have sex with men (T/GBM). We measured vaccine uptake and associated factors among T/GBM clients of an urban STI clinic in British Columbia (BC)
TB is often reported in people with HIV, in whom isoniazid preventive therapy (IPT) is a treamtent regimen used to prevent TB infection. However, when mothers with HIV recieived IPT during their pregnancy, their babies were associated with an increased risk low birth weight, preterm birth, and becoming under weight. Males seemed to be particularly effected. This brings into question the use of IPT in pregnant women with HIV as the health-care communitry seeks to reach SDGs 3.1, 3.2, and 3.3.
