This paper supports SDG 3 by analysing the current national action plans of ten ASEAN countries and their alignment with the Global Action Plan on antimicrobial resistance, highlighting five key themes: policy design, implementation tools, monitoring and evaluation, sustainability, and One Health engagement.
Building and Environment will host a series of free webinars on COVID-19 Control. The second webinar of the series will feature 2 presentations from experts in the field on the following topics: COVID-19 and indoor and outdoor sports, presented by Bert Blocken, Professor of Civil Engineering, Eindhoven University of Technology, the Netherlands & KU Leuven, Belgium. Efficient reduction of airborne transmission by advanced ventilation, presented by Arsen K. Melikov, Professor of Ventilation and Air Distribution, Technical University of Denmark, Denmark.
A call for research into how planetary health, specifically public health, is linked to climate change and how humans are changing the planet. Climate change and biodiversity loss are impacting human immunity and disease outbreaks

Behavioural Brain Research, Volume 400, 26 February 2021

AMPK plays a key role in both diabetes mellitus (DM) and Alzheimer's disease (AD) - targeting this biomolecule and understanding the relationship with DM provides new hope for the treatment of AD
Schematic representation of the mechanism by which readthrough compounds restore channel function in G542X-CFTR–expressing cells. PTC refers to the premature termination codon.
Cystic fibrosis (CF) is caused by a mutation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, which disrupts an ion channel involved in hydration maintenance via anion homeostasis. Nearly 5% of CF patients possess one or more copies of the G542X allele, which results in a stop codon at residue 542, preventing full-length CFTR protein synthesis. Identifying small-molecule modulators of mutant CFTR biosynthesis that affect the readthrough of this and other premature termination codons to synthesize a fully functional CFTR protein represents a novel target area of drug discovery. We describe the implementation and integration for large-scale screening of a homogeneous, 1536-well functional G542X-CFTR readthrough assay. The assay uses HEK 293 cells engineered to overexpress the G542X-CFTR mutant, whose functional activity is monitored with a membrane potential dye. Cells are co-incubated with a CFTR amplifier and CFTR corrector to maximize mRNA levels and trafficking of CFTR to the cell surface. Compounds that allow translational readthrough and synthesis of functional CFTR chloride channels are reflected by changes in membrane potential in response to cAMP stimulation with forskolin and CFTR channel potentiation with genistein. Assay statistics yielded Z′ values of 0.69 ± 0.06. As further evidence of its suitability for high-throughput screening, we completed automated screening of approximately 666,000 compounds, identifying 7761 initial hits. Following secondary and tertiary assays, we identified 188 confirmed hit compounds with low and submicromolar potencies. Thus, this approach takes advantage of a phenotypic screen with high-throughput scalability to identify new small-molecule G542X-CFTR readthrough modulators.
This chapter addresses SDG 10 and SDG 3 by reviewing the explosion of research over the past 15 years on the role of segregation, and resultant differences in childhood neighborhood quality, as fundamental causes of health disparities over the life course.

Handbook of Advanced Approaches Towards Pollution Prevention and Control, 2021, Pages 281-305

This book chapter advances SDGs 3 and 6 by explaining why SDG goals toward clean water are so essential to those targeting good health.

Handbook of Aging and the Social Sciences (Ninth Edition) Handbooks of Aging 2021, Pages 131-149

This book chapter advances SDG3 Good Health and Wellbeing and SDG 10 Reducing Inequalities by examining the research on the role of segregation, and resultant differences in childhood neighborhood quality, as fundamental causes of health disparities over the life course including illness and disability.
This book chapter advances SDG3 Good Health and Wellbeing and SDG10 Reducing Inequalities by examining the role caregivers provide as a critical source of care for people living with disabilities and chronic conditions.

Barefoot Global Health Diplomacy, Field Experiences in International Relations, Security, and Epidemics, 2021, Pages 27-49

Adaptability to politics, economics, and to the wealth and poverty of the world: health programs, in emergencies or over the longer term, need to be aware of local incomes and costs of services—and how they can be paid for. Programs and projects and interventions should thus evolve to make sure the treatment, the testing, the assistance they are promoting is available and affordable—both when the internationals are there, and after they leave