Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal degeneration, Pick’s disease, and the largest cause of dementia, Alzheimer’s disease. The lack of disease-modifying therapeutic strategies to address tauopathies remains a critical unmet need in dementia care. Thus, novel broad-spectrum tau-targeted therapeutics could have a profound impact in multiple tauopathy disorders, including Alzheimer’s disease. Here we have designed a drug discovery paradigm to identify inhibitors of the pathological tau-enabling protein, MSUT2. We previously showed that activity of the RNA-binding protein MSUT2 drives tauopathy, including tau-mediated neurodegeneration and cognitive dysfunction, in mouse models. Thus, we hypothesized that MSUT2 inhibitors could be therapeutic for tauopathy disorders.
Material depletion over reliance of linear economies and environmental pollution may be resolved by applying the principles and practices of anthropogenic circularity science. Here we systematically review the emergence of anthropogenic circularity science in the interdisciplinary development of green chemistry, supply chain, and industrial ecology at different scales.
On March 21, The International Day for the Elimination of Racial Discrimination is observed annually on the day the police in Sharpeville, South Africa, opened fire and killed 69 people at a peaceful demonstration against apartheid "pass laws" in 1960. This year’s 2021 theme is “Youth standing up against racism”. It engages the public through #FightRacism, which aims to foster a global culture of tolerance, equality and anti-discrimination and calls on each and every one of us to stand up against racial prejudice and intolerant attitudes. To engage, highlight, and raise awareness on racial discrimination, Elsevier presents a curated list of free access journal articles and book chapters. At Elsevier, we will #Standup4humanrights and send the message that racism is unacceptable everywhere.
Nutritional value is imperative for food security. Understanding how breeding can enhance this is an important tool toward eliminating hunger and food insecurity.
Hematopoietic stem cells (HSCs) are responsible for life-long production of blood and immune cells. HSC transplantation (HSCT) is the original cell therapy which can cure hematological disorders but also has the potential to treat other diseases if technical and safety barriers are overcome. It is hoped that HSCT can become safe enough to treat non-life-threatening disorders like allergy, psychiatric disorders, HIV, and aging.
RELX’s Global Head of Corporate Responsibility, Dr Márcia Balisciano, talks to Dr. Marianne Legato about gender-specific medicine.
What vaccines are currently available? How will they help? Are they safe? Is Covid-19 here to stay and will there be more pandemics? Just some of the questions answered by John McConnell, Editor, The Lancet Infectious Diseases.
In recognition of International Women’s Day (IWD), Elsevier, a global leader in information analytics specializing in science and health, has launched a free access special issue of curated content focused on women and gender issues in health and sciences.
Elsevier,
Chris D. Jones, Chapter 4 - Numerical modeling of the global climate and carbon cycle system, Editor(s): Trevor M. Letcher, Climate Change (Third Edition), Elsevier, 2021, Pages 67-91
This chapter advances SDGs 13 and 15 by applying numerical modeling techniques to better understand the global climate and utilize observations to identify impacts of climate change on Earth.
Elsevier,
Trevor M. Letcher, 1 - Global warming—a complex situation, Editor(s): Trevor M. Letcher, Climate Change (Third Edition), Elsevier, 2021, Pages 3-17
This book chapter advances SDGs 13 and 15 by examining how pollution and greenhouse gases contribute to global warming, as well as addressing the social and ethical impacts of climate change.
