Elsevier,
Clinical Neuroepidemiology of Acute and Chronic Disorders, First Edition, 2023, pp 199-211
This chapter advances the UN SDG goals 3 and 17 by reviewing the basics understandings of delirium and dementia.
Alzheimer disease (AD) is a neurodegenerative condition defined by the build-up of amyloid plaques in the brain and intraneuronal tangles of the protein tau. Autophagy is a cellular cleaning process involved in the degradation of proteins, including proteins directly responsible for amyloid plaques, but its activity is compromised in AD. This study showed that reducing dietary protein intake can reduce mTORC1 activity and amyloid plaque deposition in the brains of male mice with a less aggressive model of Alzheimer's disease, but not in a more aggressive model or in female mice.
This review discusses the critical role of oxidative stress in the pathogenesis of neurological disorders such as stroke and Alzheimer's disease (AD), detailing the mechanisms of reactive oxygen species (ROS) generation in the brain and exploring the potential of antioxidant therapies as therapeutic targets.
Nitric Oxide can act as both protecting and aggravating factor in Alzheimer's Disease. Nitric oxide can be considered as a neurotoxic factor in Alzheimer's Disease. Nitric Oxide induces neuro plasticity, neuroprotection, neurogenesis, long-term potentiation, and myelination. Drugs based on Nitric Oxide have shown promising results in Alzheimer's Disease. Nitric Oxide can via sundry ways ameliorate memory formation.
The living infinite: Envisioning futures for transformed human-nature relationships on the high seas
Marine Policy, Volume 153, 2023, 105644, ISSN 0308-597X
We are at a critical crossroads for the future governance of the high seas. We used the Nature Futures Framework to explore desirable futures for the high seas. Creative endeavours of co-production encourage imagination to address challenges. Participatory processes are important tools in the science-policy interface. Stories and art can be powerful ways to overcome barriers.
This study aims to identify the factors that constrain and enable the sustainability of reusable packaging systems, considering environmental, economic, social and technical dimensions. This research is critical to the effective implementation and scale-up of reusable packaging systems.
Dolutegravir is the globally recommended first-line therapy for HIV. In this paper researchers assess the effects of dolutegravir roll-out in the country with the highest HIV burden.
Richard et al. provide extensive evidence suggesting that treatment with the HIV-1 attachment inhibitor temsavir can have beneficial effects that extend beyond viral neutralization, notably by preventing elimination of uninfected cells and induction of a cytokine burst caused by its soluble viral glycoprotein.
This Article supports SDG 3 by comparing epigenetic ageing during untreated HIV infection and during HIV being treated with antiretroviral therapy. They found that epigenetic ageing was accelarated during the former and decelerated during the latter.
Early treatment of HIV is essential for the health of infants living with HIV; this study looks at ways to improve case-finding.
