This study observes that oxidative dame in Alzheimer's Diseases is a pathogenic mechanism at the cell-tissue level.
In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
Background: Air pollution, road traffic noise, and green space are correlated factors, associated with risk of stroke.
This study links multiple models for a comprehensive assessment of the economic-environmental-health co-benefits of renewable energy development in China. The results show that developing renewable energy can avoid 0.6 million premature mortalities, 151 million morbidities, and 111 million work-loss days in 2050.
This content aligns with Goal 3: Good Health and Wellbeing by discussing the medical applications and limitations of five US Food and Drug Administration–approved INSTIs for the treatment of HIV/AIDS and preexposure prophylaxis for HIV-1.
This content aligns with Goal 3: Good Health and Wellbeing by discussing 310 tiglianes reported during 1967–2022, including the mechanisms of action of tiglianes against HIV and discusses the anti-HIV structure–activity relationship of certain tiglianes.
PHQ-8 could be used for screening and severity assesment of depressive symptoms at the European level.
One of the important adverse impacts of climate change on human health is increases in allergic respiratory diseases such as allergic rhinitis and asthma.
This Health Policy paper supports SDGs 2, 3, and 13, by identifying and examining the debates that arose from the publication of the EAT–Lancet Commission, systematically examining how research has been directly influenced by the Commission, and synthesising identified research gaps to build a research agenda for healthy and sustainable food systems.
Background: Over the past three decades, the prevalence of adolescent emotional problems (ie, anxiety and depression) has risen.
