An ongoing challenge in HIV-1 vaccine research is finding a novel HIV-1 envelope glycoprotein (Env)-based immunogen that elicits broadly cross-neutralizing antibodies (bnAbs) without requiring complex sequential immunization regimens to drive the required antibody affinity maturation. 
Cabotegravir (CAB) is an integrase strand transfer inhibitor (INSTI) formulated as a long-acting injectable drug approved for pre-exposure prophylaxis and use with a long acting rilpivirine formulation for therapy in patients with virological suppression. However, there has been no comprehensive review of the genetic mechanisms of CAB resistance. Studies reporting the selection of drug resistance mutations (DRMs) by CAB and the results of in vitro CAB susceptibility testing were reviewed.
Figure 1. Maternal physiological responses to thermal heat stress
This Article supports SDGs 3, 5, and 13, focusing on the mechanisms for adverse outcomes caused by environmental heat stress in pregnant subsistence farmers.
Elsevier,

The Lancet Planetary Health, Volume 6, Issue 12, December 2022, Pages e941-e948

This Article supports SDGs 3 and 13 by estimating cost and benefits of climate change mitigation, focussing on heat-related labour losses and considering current mitigation pledges.
This article ties to SDG 3. It reviews converging lines of evidence that suggest that development of prefrontal cortical circuitry necessary for both social experiences and fear learning is altered by stress exposure in a way that impacts both social and fear behaviors throughout the lifespan.
The paper shows how still births are distributed across the country and how these regions need more focus in the UHC policy.
Elsevier,

Clinical Breast Cancer, Volume 23, Issue 2, February 2023, Pages 181-188

This Study supports SDGs 3, 5 and 10 by exploring the national impact of limited English proficiency (LEP) in breast cancer screening. Previously unknown, the results showed that LEP women, particularly Spanish speakers, are associated with a lower probability of having a screening mammogram.
This Climate Countdown paper supports SDGs 3 and 13 by summarising procress through 27 climate indicators in China from 2021 to 2022.
Elsevier,

Clinical Breast Cancer, Volume 23, Issue 2, February 2023, Pages 211-218

This Study supports SDGs 3, 5 and 10 by highlighting the significant variability in insurance coverage of Prophylactic Mastectomy (PM) between companies which can lead to further inequalities in access to this breast cancer risk reducing procedure. Physicians and patients alike should advocate for fair and equal access to PM for certain clinical indications.
Development of plant based meat analogues for sustainable food systems.

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