This Health Policy paper supports SDG 3 and 13 by examining countries' preparedness and inclusion of child health as it relates to climate change, highlighting both how countries integrate child health within adaptation domains and how policy documents conceptualise children.This Health Policy paper supports SDG 3 and 13 by examining countries' preparedness and inclusion of child health as it relates to climate change, highlighting both how countries integrate child health within adaptation domains and how policy documents conceptualise children.
Indigenous Peoples face disproportionate risks from climate change while being key to planetary health and climate resilience due to their traditional ecological knowledge. This manuscript provides Indigenous perspectives on climate justice, exploring the intersection of health, sovereignty, and ancestral practices, and discusses opportunities for decolonizing relationships to place, highlighting a case of rematriation and healing at Bdóte, the place of genesis for Dakota Peoples, also known as Minneapolis and Saint Paul, MN.
To optimize the delivery of culturally safe care, health systems need to rebuild their relationship with Indigenous peoples.
This Article supports SDG 3 by assessing the effectiveness of specialist physiotherapy for functional motor disorder and finding that future research should refine interventions for this population and develop evidence-based methods to guide treatment.
The results of this study emphasize the importance of considering lifestyle aspects like sleep, physical activity, and social support when creating effective strategies to prevent depression in university students.
This study aimed to examine relationships among eating frequency, timing and time window, and cognitive performance and novel Alzheimer disease (AD) biomarkers in cognitively healthy and mildly cognitively impaired middle-aged and older adults. It concluded that an eating pattern characterized by less frequent eating and/or by earlier times is present in individuals with worse cognitive performance. The results shed light on the relevance of temporal eating patterns as potential early markers of behavioral or metabolic changes related to AD pathology.
This article provides evidence that disruption of the intestinal mucosal barrier contributes to sarcopenia and functional dependence in patients with AD. RE may be an effective therapy to strengthen the intestinal mucosal barrier, reduce sarcopenia, and improve functional performance in patients with AD.
This review provides a comprehensive overview of both conventional and novel therapeutic strategies for Alzheimer's disease (AD), highlighting traditional Acetylcholinesterase (AChE) inhibition and emerging approaches such as Butyrylcholinesterase (BChE) inhibition, Tau Protein inhibitors, and COX-2 inhibition, while also exploring the roles of endocannabinoids, cholesterol-lowering drugs, and microRNA, alongside novel research tools and current clinical trials, to offer a consolidated resource for advancing AD treatment and research.
This study found that Alzheimer’s disease neuropathological change (ADNC) is associated with gene expression changes that may impair cholesterol biosynthesis in neurones but not astrocytes, whilst levels of cortical cholesterol show a weak relationship to dementia status.
Every year, 10 million people develop dementia, most commonly Alzheimer's disease (AD), and despite limited therapies and no prevention for cognitive decline, this review offers a neuroimmunological perspective on AD progression, focusing on the role of the NLRP3 inflammasome, its brain triggers, and the potential impact of various NLRP3 inhibitors currently under investigation in preclinical and clinical trials.
