Neurological disorders affect approximately one billion people worldwide, with significant disability and mortality impacts, and this review explores how Heparan sulfate proteoglycans (HSPGs) promote Tau fibril formation and tangles in Alzheimer's disease, and the potential role of tunnelling nanotubes (TNTs) in the intercellular transport of Tau and Amyloid β proteins, suggesting that HSPGs may influence TNT formation in neurodegenerative conditions.
This study reveals that Dl-3-n-butylphthalide (NBP) improves learning deficits and reduces Aβ plaque deposition in Alzheimer's disease (AD) transgenic mice by enhancing microglial activation and phagocytosis of Aβ plaques. The therapeutic effects of NBP are linked to the AGE-RAGE signaling pathway, demonstrating its potential in alleviating cognitive impairment and neuroinflammation in AD.
This Article supports SDG3 by evaluating sex and gender disparities in terms of risk factors, treatment uptake/completion, and virological outcomes for hepatitis C, finding differences between men and women in, for example, exposure to different risk factors and likelihood of commencing treatment. More attention is needed in research to these disparities and how they could be addressed
Elsevier,

Canadian Journal of Cardiology, Volume 40, June 2024

This review article summarizes the current evidence for culturally adapted cardiac rehabilitation programming for Indigenous patients, including community engagement. strategies to improve education on cardiovascular risk-factor optimization and to promote guideline-based exercise and diet programs through an Indigenous perspective.

This study, led by Indigenous scholars at the University of Queensland, examines the health and social outcomes of Indigenous peoples and health workers during pandemics in urban settings. The study incorporates systems thinking, emphasising new approaches to complex problems. The research highlighted systemic challenges in pandemic responses, emphasising the need for policy reform, particularly in areas like housing.

The findings contribute to a deeper understanding of the unique social and emotional wellbeing needs of Aboriginal and Torres Strait Islander peoples accessing home-based aged care services and have significant implications for current and future aged care reforms in Australia.

The study introduces a nano-modulator that targets the damaged blood-brain barrier in Alzheimer’s disease. This modulator releases therapeutic agents that reduce amyloid-beta load, alleviate neuroinflammation, and restore neurovascular unit function, showing potential for Alzheimer’s treatment.

This study aimed to assess the correlation between antidiabetic agents and platelet characteristics, hoping to provide a potential mechanism of TZDs neuroprotection in AD
This study investigated VGLUT1 and VGLUT2 expression in the medial temporal lobe and superior temporal gyrus in Alzheimer's disease (AD). The findings reveal region-specific vulnerabilities, with significantly lower VGLUT1 in the dentate gyrus and VGLUT2 in the subiculum and superior temporal gyrus, suggesting potential therapeutic targets that require further exploration.
This article explores the link between alcohol consumption and Alzheimer’s disease (AD), focusing on how serotonergic dysfunction may mediate this relationship. It highlights the roles of neuroinflammation and proteostasis in this process

Pages