Organoids are three-dimensional, functional structures that mimic in vivo organs. They offer new opportunities for the modeling of cancer and infectious and rare hereditary diseases. Furthermore, the advent of organoid biobanks opens new avenues for drug screening in a personalized fashion and holds much promise for personalized regenerative medicine. Thus, there is a need for reproducible, large-scale organoid generation with minimal variability, making manual approaches impracticable. Here, we review the current use of automation in organoid culture and analysis, using cerebral and retinal organoids as illustrations of current applications. An increased demand for automated organoid platforms is anticipated.
Elsevier,
Boissonneault, M. and Rios, P., 2021. Changes in healthy and unhealthy working-life expectancy over the period 2002–17: a population-based study in people aged 51–65 years in 14 OECD countries. The Lancet Healthy Longevity, 2(10), pp.e629-e638.
This study supports SDGs 3 and 8 by estimating the healthy and unhealthy working-life expectancy in 14 countries between 2002 and 2017. The study used cross-sectional data from surveys on ageing. Across all countries, increases in the number of years working were accompanied by an increased number of unhealthy working years, most frequently due to hypertension or arthritis.
BACKGROUND: Many regions of the world are now facing more frequent and unprecedentedly large wildfires.
Climate change is impacting the life, health, and security of people worldwide with poor communities and displaced populations at particular risk due to lack of awareness and mitigation plans.
Artificial intelligence (AI) is a rapidly developing field contributing to the English National Health Service (NHS) goals of more efficient care and reduced climate impact.
This paper presents an initial qualitative exploration of United States physicians’ perspectives with regard to whether, why and how physicians might discuss the health effects of global environmental change, climate change in particular, with their patients and what would need to change in healthcare systems to facilitate this.
This investigation describes patient and family responses to climate change counselling administered by one pediatrician in a Wisconsin clinic.
This article discusses current initiatives in several areas to contribute to a climate resilient Bahamas, and prioritizing mental health and psychosocial support for survivors of climate disasters.
The novel coronavirus disease 2019 (COVID-19) has pushed the medical system to its breaking point.
Rho-associated coiled-coil kinase (ROCK), a serine/threonine kinase regulated by the small GTPase RhoA, is involved in regulating cell migration, proliferation, and survival.
