This study identifies research trends and hotspots on the comorbidity between periodontitis and neurodegenerative diseases, incl. Alzheimer's.
The objective of this study was to assess the neuropsychological characteristics of individuals with early-onset Alzheimer's disease (EOAD), late-onset Alzheimer's disease (LOAD), and very-late-onset Alzheimer's disease (VLOAD). The findings indicate notable neuropsychological variations across different age groups, demonstrating a progressive decline in cognitive function with age rather than distinct clinical presentations.
The authors put forward a mathematical model for examining the impact of water, sanitation and hygiene (WASH) services on reducing the transmission of waterborne diseases such as enteric diarrheal disease (EDD). It is found that wastewater and sewage treatment (WST) control has the most significant impact in terms of WASH interventions employed. The findings have could have very important public health potential and tie in strongly with the goals of SDG 6.
This article supports SDG 3 as understanding the role of HCV core proteins in viral diseases is crucial to elucidating disease mechanisms and identifying potential drug targets. However, purification challenges may hinder the comprehensive elucidation of the structure and biochemical properties of HCV core proteins.
In Alzheimer's disease research, cerebrospinal fluid (CSF) biomarkers Amyloid beta (Aβ), Tau, and pTau are well-validated, and this study demonstrates that a Z-score based harmonization approach can effectively standardize CSF and amyloid imaging data across multiple cohorts, providing consistent biomarker cut-offs and comparable GWAS results to traditional methods, without introducing spurious findings.
This article discusses the manifestation of apathy-like behaviors in Alzheimer's disease (AD) and frontotemporal dementia (FTD) mouse models through the assessment of nest-building behavior, highlighting differences in nesting proficiency and anhedonia between tau transgenic mice lines, suggesting apathy-like phenotypes in the context of neurodegenerative diseases.
This study supports SDGs 3, 6, and 14 by highlighting the importance of freshwater biodiversity for human and planetary health, and suggesting that local and regional efforts for monitoring and improving ecosystem health are essential for reversing the current crisis in this area.
This Article supports SDG 3 sequencing hepatitis C virus genomes in west Africa, showing the level of genotypic diversity and measuring the response to direct-acting antivirals.
This Article supports SDG 3 by estimating the prevalence of chronic hepatitis C virus infection in Europe and suggesting that EU countries need to scale up testing and treatment linkage, as well as review overall strategies for hepatitis prevention.
This Article supports SDG 3 by showing that mobile health clinics can be a feasible and effective way of providing hepatitis C services to underserved, at-risk populations who face barriers to care. Policymakers should consider implementing such programmes in order to increase diagnosis and treatment rates and improve outcomes among these populations.
