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Real-world evidence can supplement clinical trial data to optimize Alzheimer’s disease care by aiding early patient identification and assessing drug effectiveness and safety in everyday use in diverse clinical settings/populations. This information helps inform clinical practice guidelines and supports the development of tools for timely diagnosis and personalized treatment strategies.
The article discusses advancements in using 3D models and human iPSC-derived microglia to study neurodevelopment and neurological disorders, highlighting their potential for understanding brain development, microglial functions, and disease mechanisms. It also explores various models, including organoids and xenotransplantation, and their applications in studying conditions like Alzheimer’s, Parkinson’s, and autism.
This systematic review examined the relationship between cognition and motor speech production in healthy older adults and those with mild cognitive impairment, analyzing 22 studies with 747 participants. Findings suggest that cognitive functions, particularly attention and executive abilities, are linked to motor speech performance, though evidence quality varies and gaps remain.

World Telecommunication and Information Society Day is an annual celebration on May 17th. To raise awareness for this important topic, Elsevier presents a curated list of publicly available journal articles and book chapters to help advance #SDG9 and #SDG10 research.

Elsevier,

 

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Despite global progress, maternal mortality remains high, especially in sub-Saharan Africa, highlighting the urgent need for strong leadership, increased investment in well-trained midwives, and equitable, culturally sensitive maternity care to achieve the Sustainable Development Goal of reducing maternal deaths to less than 70 per 100,000 live births by 2030.

This study identified over 2,000 proteins in cerebrospinal fluid that change at different stages before Alzheimer's symptoms appear, revealing key biological processes involved in the disease. Using machine learning, the researchers developed highly accurate models to predict Alzheimer's biomarker status, clinical diagnosis, and future disease progression.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by providing an overview of the cholinergic hypothesis of Alzheimer's Disease and potential innovations in cholinergic therapies.

The Future of Philanthropy: Stepping up for the UN Sustainable Development Goals
Join us for RELX SDG Inspiration Day 2025 - a free, online event to explore issues, gain practical insights and be inspired to take action in support of the N SDGs.

The protein-enriched oral nutritional supplement helped maintain lean body mass and prevent fat gain in middle-aged and elderly women. This suggests its potential role in preventing frailty and musculoskeletal disorders associated with female aging.
In this episode of the "World We Want" podcast, Márcia Balisciano interviews Teresa Njoroge, Founder and CEO, Clean Start Africa. They discuss about Clean Start Africa’s efforts to provide employment training, psychological support, and vocational and entrepreneurship programs to communities affected by the justice system, helping them build sustainable livelihoods after release.

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