The article presents PI4AD, a computational medicine framework that integrates multi-omics data, systems biology, and artificial neural networks to prioritize therapeutic targets for Alzheimer's disease (AD). PI4AD recovers clinically validated targets like APP and ESR1, confirming its prioritization efficacy. The framework identifies Ras signaling as a central therapeutic hub, complementing traditional amyloid/tau-focused approaches. Crosstalk analysis reveals critical nodal genes (e.g., HRAS and MAPK1) and drug repurposing opportunities, bridging genetic insights with pathway-level biology.
This review highlights how nurse practitioners can strengthen Alzheimer’s disease care by supporting earlier diagnosis and access to treatment, which is essential for maintaining quality of life. Expanding their role helps reduce barriers in the healthcare system, ensuring people with Alzheimer’s receive timely care that promotes better health and well-being.
The article suggest that beta-amyloid protein (Aβ) has a significant indirect effect on neurogranin (Ng) through key synaptic mediators such as SYT1 and GAP43 during the preclinical stages of Alzheimer’s disease (AD). These findings highlight the crucial role of SYT1 and GAP43 in mediating beta-amyloid-induced synaptic dysfunction, offering potential early biomarkers and therapeutic targets for AD progression.
This chapter aligns with UN SDG Goals 6 and 14 by addressing how anthropogenic impacts to water quality affect marine fish populations and discussing future perspectives for managing water quality and aquatic habitats.
Elsevier,
Advanced Technologies in Wastewater Treatment: Waste Water Treatment of Leather Industry, 2025, Pages 63-92
This chapter aligns with UN SDG Goals 6, 9 and 12 by promoting clean water, reducing pollution, and supporting sustainable water management practices.
Outlining how vehicle electrification in low-income countries can help EVs achieve the goals of sustainable mobility.
This study projects the energy cneeds and carbon footprints of energy centres in Germany by 2030 and maps the pathway towards zero emissions.
Emerging pollutants (EPs), such as pharmaceuticals and personal care products (particularly antibiotics) and microplastics, pose significant threats to global water quality and human health, leading to increased interest in the use of constructed wetlands (CWs) for their purification. This paper reviews the literature from 2014 to 2024 on CWs' effectiveness in removing various EPs.
This review examines the use of cover plants for remediating various contaminants, including metals, organic pollutants, nitrates, antibiotics, antimicrobial resistance genes, plastics, and salts.
Daytime radiative cooling and photovoltaic energy generation are poorly compatible, as they have competing physical demands. Here, a transmission-based radiative cooling system is integrated with solar cells, allowing simultaneous cooling and photovoltaic power generation in sunny weather.
