This review provides a comprehensive overview of both conventional and novel therapeutic strategies for Alzheimer's disease (AD), highlighting traditional Acetylcholinesterase (AChE) inhibition and emerging approaches such as Butyrylcholinesterase (BChE) inhibition, Tau Protein inhibitors, and COX-2 inhibition, while also exploring the roles of endocannabinoids, cholesterol-lowering drugs, and microRNA, alongside novel research tools and current clinical trials, to offer a consolidated resource for advancing AD treatment and research.
This study aimed to examine relationships among eating frequency, timing and time window, and cognitive performance and novel Alzheimer disease (AD) biomarkers in cognitively healthy and mildly cognitively impaired middle-aged and older adults. It concluded that an eating pattern characterized by less frequent eating and/or by earlier times is present in individuals with worse cognitive performance. The results shed light on the relevance of temporal eating patterns as potential early markers of behavioral or metabolic changes related to AD pathology.
With evident relevance to SDG 6, the research explores a water pollution control technology evaluation model based on the Pythagorean language neutrosophic set (PLNS) in the context of the pulp and paper industry. The authors' model aims to assist in the choice of appropriate water pollution control technology for those working within the paper industry. It is tested in an example based in China.
The study discusses the latest developments in Alzheimer’s disease treatment, with a focus on monoclonal antibodies and aptamers. It covers the current state of therapies, recent drug approvals, and future perspectives on immunotherapeutic strategies.
Every year, 10 million people develop dementia, most commonly Alzheimer's disease (AD), and despite limited therapies and no prevention for cognitive decline, this review offers a neuroimmunological perspective on AD progression, focusing on the role of the NLRP3 inflammasome, its brain triggers, and the potential impact of various NLRP3 inhibitors currently under investigation in preclinical and clinical trials.
This article discusses the impact of methionine oxidation on clusterin function in Alzheimer's disease, highlighting the elevated levels of MetO-clusterin in human and mouse brains affected by the disease, and how this oxidation compromises clusterin's chaperone function, potentially exacerbating beta-amyloid toxicity in Alzheimer's pathology.
This study found that Alzheimer’s disease neuropathological change (ADNC) is associated with gene expression changes that may impair cholesterol biosynthesis in neurones but not astrocytes, whilst levels of cortical cholesterol show a weak relationship to dementia status.
This study supports SDG 3 by analyzing expenditures on hepatitis B treatments, promoting better health resource management.
The aim of the paper is to understand the culture around birth and indigenous people. This study aimed to understand First Nations women’s perceptions of placenta burial and a dedicated placenta garden in supporting connection to their culture.
Although Indigenous Australians critically ill with sepsis have similar short and long-term mortality rates, they present to hospital, die in-hospital, and die post-discharge significantly younger. Unique cohort characteristics may explain these outcomes, and assist clinicians, researchers and policy-makers in targeting interventions to these characteristics to best reduce the burden of sepsis in this cohort and improve their healthcare outcomes.
