Climate change can have detrimental effects on child health and wellbeing.
A Research Paper on food insecurity in the UK, in the context of SDGs 1, 2, and 3, focusing specifically on the association between the implementation of austerity policies in 2010 and the increase in foodbank use and food insecurity over the following decade.
Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal degeneration, Pick’s disease, and the largest cause of dementia, Alzheimer’s disease. The lack of disease-modifying therapeutic strategies to address tauopathies remains a critical unmet need in dementia care. Thus, novel broad-spectrum tau-targeted therapeutics could have a profound impact in multiple tauopathy disorders, including Alzheimer’s disease. Here we have designed a drug discovery paradigm to identify inhibitors of the pathological tau-enabling protein, MSUT2. We previously showed that activity of the RNA-binding protein MSUT2 drives tauopathy, including tau-mediated neurodegeneration and cognitive dysfunction, in mouse models. Thus, we hypothesized that MSUT2 inhibitors could be therapeutic for tauopathy disorders.
Hematopoietic stem cells (HSCs) are responsible for life-long production of blood and immune cells. HSC transplantation (HSCT) is the original cell therapy which can cure hematological disorders but also has the potential to treat other diseases if technical and safety barriers are overcome. It is hoped that HSCT can become safe enough to treat non-life-threatening disorders like allergy, psychiatric disorders, HIV, and aging.
Blood donation saves lives, and the communication between blood centers and donors plays a vital role in this. Smart apps are now considered an important communication tool, and could be best utilized in blood donation if they are designed to fit the users’ needs and preferences.
This Article supports SDG 3 by highlighting the benefits of equipping a wider (non-specialist) workforce to deal with the demands of population screening for rare diseases such as spinal muscular atrophy through education programmes and access to expert opinions.
A review on dementia in low-income and middle-income countries, in the context of SDGs 3 and 10, focusing specifically on culturally appropriate treatments and the need for more effectiveness trials on adapted interventions.
The article examines the link between physical activity earlier in life and a lower risk of dementia later in life.
The nature of armed conflict throughout the world is intensely dynamic.
Complementary Feeding (CF) involves an array of behaviors ranging from producing or purchasing food to preparing and feeding it to the child. Nutrition-specific and nutrition-sensitive interventions support different dimensions of improved CF, including dietary diversity, adequate frequency and daily intake, food hygiene, responsive feeding, and parenting practices. Beyond messages specific to what to feed young children, interventions to improve CF could address norms related to early child development; family dynamics; water, sanitation, and hygiene (WASH)
