This Personal View makes a contribution to Sustainable Development Goal 3 by summarising the advances is early detection, drug development, and trial methodology which the authors argue should be used in brain health clinics to develop new therapies for Alzheimer's disease.
Elsevier,
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Volume 883-884, 1 November 2022
This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and prenatal genotoxic exposure.
To help create awareness and observe the International Day of Persons with Disabilities (IDPD) on 3 December 2022, Elsevier is proud to showcase a special issue of freely available journal articles and book chapters to share.
This Study supports SDGs 3, 5 and 10, investigating the impact of chemotherapy on the immune system of older women with breast cancer.
DNA glycosylase Neil3 leads to sex-specific differences in AD. Neil3 increases plaque deposition in female APP/PS1 mice. Neil3 promotes hippocampal neurogenesis and working memory in male APP/PS1 mice. Neil3-dependent DNA damage accumulation does not correlate with AD pathogenesis.
Based on current studies, the incidence of Ewing sarcoma (ES) varies significantly by race and ethnicity, with the disease being most common in patients of European ancestry. However, race/ethnicity has generally been self-reported rather than formally evaluated at a population level using DNA evidence. Additionally, mitochondrial dysfunction is a hallmark of ES, yet there have been no reported studies of mitochondrial genetics in ES. Thus, we evaluated both the mitochondrial and nuclear ancestries of 420 pediatric ES patients in the United States using whole-genome sequencing.
This Article supports SDG 3 and 5 by demonstrating the need to better understand the roles that male partners play in encouraging or discouraging care-seeking behaviours during pregnancy and the postpartum period.
The Lancet Global Health, available online 11 October 2022, in press.
An Article in support of SDGs 3, 5, and 10, showing that effective cataract surgical coverage varies widely between countries, increases with greater income level, and is higher in men.
The annual UN Climate Change Conference advances climate talks, mobilizes action, and can provide a significant opportunity to look at the impacts of climate change as well as innovation and solutions globally. Elsevier is pleased to showcase a large number of freely accessible journal articles and book chapters to help advance research and action against climate change, as well as a podcast episode, in support of COP27.
This chapter advances the UN SDG Goal 3: Good Health and Goal 10: Reduced Inequalities by outlining the approaches that can be broadly applied to improve health equity and reduce disparities in perioperative care.