Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

Elsevier, Journal of Vascular Surgery, Volume 82, September 2025
Objective: In several countries, including the United States and United Kingdom, screening tests are conducted on men 65 years of age or older who smoke to diagnose abdominal aortic aneurysm (AAA) before rupture. In women, however, the incidence of AAA is low, so screening tests are not cost effective and therefore not recommended. Early detection and treatment of AAA are important for women as they face a four times higher risk of rupture and worse surgery outcomes compared with men.
Elsevier, American Journal of Preventive Cardiology, Volume 23, September 2025
Lifestyle factors, including physical activity, dietary patterns, sleep, stress response, social connections, and use of risky substances, are increasingly recognized as predictors of cardiovascular disease (CVD) and cardiovascular health, with significant overlap between the American Heart Association's Life's Essential 8 guidelines and the 6 pillars of Lifestyle Medicine (LM). Assessing and addressing lifestyle factors have a foundational role in the prevention and management of cardiovascular disease and improving cardiovascular health.
This study explores how students’ autonomy, competence, and relatedness at school relate to their wellbeing, focusing on girls, students with special educational needs (SEN), and low socioeconomic status (SES) students
This article analyses over 1,200 legal and policy documents from 193 countries to assess global efforts toward educational equity, focusing on barriers related to income, disability, gender, and discrimination. It reveals significant gaps, including tuition fees before secondary school, lack of protections against sexual harassment and disability discrimination, and limited provisions for inclusive education.
Elsevier,

Endocrine Practice

Volume 31, Issue 9, Supplement, September 2025, Page S193

 

Evidence from preclinical research suggests that dysfunction in thyroid hormones may increase ?-amyloid levels and tau phosphorylation, 2 hallmark features of Alzheimer's Disease(AD). This study showed a strong association between hypothyroidism and AD mortality.

Elsevier,

Advancing Brain Cancer Care: Precision, AI Innovation, and African Insights, 2025, pp 209-231

This chapter explores how big data analytics and advanced methodologies like multiomics and AI are transforming brain cancer research, enabling early diagnosis, personalized treatment, and targeted prevention. By improving health outcomes through precision oncology (SDG 3: Good Health and Well-being) and addressing global disparities in cancer care via collaborative initiatives and equitable access (SDG 10: Reduced Inequalities), these data-driven approaches reshape the future of brain cancer treatment worldwide.
This study investigated how repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training affects functional connectivity in both gray matter and white matter in patients with mild to moderate Alzheimer’s disease. Results showed that rTMS modulated activity in key brain regions, particularly within the limbic system, with changes in white matter connectivity correlating with cognitive improvements.
Elsevier,

Journal of Prevention of Alzheimer's Disease, Volume 12, 1 August 2025

The study found that long-duration and high-intensity walking were associated with reduced amyloid-beta accumulation over 4 years, with the greatest benefits seen in those who started walking earlier in life. However, walking activity was not linked to changes in tau deposition, neurodegeneration, or white matter hyperintensities.
The article provides a comprehensive overview of the role of the endogenous detoxification system in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). It highlights epidemiological evidence linking environmental toxicant exposure to the onset and progression of these diseases, and discusses how dysfunction of detoxification pathways, including enzymes and transporters, can exacerbate neurodegenerative processes. The article also explores the potential of targeting nuclear receptor signaling pathways, such as the pregnane X receptor (PXR), as a promising therapeutic strategy to restore detoxification capacity and modify disease trajectories.
The article estimates the value-based price of a blood test for Alzheimer's disease pathology, finding it would be $290-$1150 in primary care and $450-$1950 in specialty care, projecting substantial cost savings.

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