Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

This content aligns with Goal 3: Good Health and Wellbeing and Goal 9: Industry, Innovation, and Infrastructure by providing an overview of the cholinergic hypothesis of Alzheimer's Disease and potential innovations in cholinergic therapies.

The "Multigenerational Resilience Theory" highlights the cultural and intergenerational nature of resilience in indigenous communities, offering new strategies for addressing modern challenges.

This article outlines a theory of goodness, coupled with some of its practical implications for impact-making, governance and lives more generally. The theory proposes that goodness consists of positive feelings and whatever promotes them, such as the joy of a meaningful conversation or the satisfaction of eating food, for instance. Although it is a version of ethical hedonism, the theory is also called welfarism since it allocates a central role to affect and since affect is central to some prevalent measures of 'subjective wellbeing'.

Drivers of health disparities in rheumatology are numerous and complex, existing within and between populations. These impact access to advanced therapies, specialized services, and core components of care.

International Day of Sport for Development and Peace 2026: Sport as a Bridge for Inclusion and Unity

This study demonstrated that physical exercise pretreatment improves recognition memory and enhances structural synaptic plasticity in the hippocampus of Alzheimer’s disease (AD) rats, primarily through the activation of hippocampal TREM2. Blocking TREM2 diminished these neuroprotective effects, indicating that exercise mitigates synaptic injury and cognitive decline in AD via a TREM2-dependent mechanism.
This study identifies two CSF proteomic panels that accurately stage Alzheimer’s pathology, outperform current biomarkers, and predict dementia progression over 10 years, enhancing diagnosis and clinical trial stratification.
The article describes the discovery and development of compound 8e, a selective and reversible butyrylcholinesterase (BuChE) inhibitor, as a potential therapeutic agent for treating Alzheimer's disease (AD). Compound 8e exhibited favorable blood-brain barrier permeability, good drug-likeness properties, and pronounced neuroprotective efficacy in various AD models, including zebrafish, scopolamine-induced mice, and APP/PS1 transgenic mice.

This backstory highlights the importance of interdisciplinary and participatory approaches in advancing the One Health concept, using lessons from an international workshop in Lao PDR to address existing knowledge gaps and improve global health security strategies.

Elsevier,

International Journal of Clinical and Health Psychology, Volume 25, 1 April 2025

This study provides evidence of distinct alterations in resting-state functional connectivity in individuals with amnestic mild cognitive impairment (aMCI) and late-life depression (LLD), underscoring region-specific vulnerabilities that may contribute to cognitive decline and depressive symptomatology in older adults.

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