Health and wellbeing

Health and well-being have a central role in the 17 Sustainable Development Goals (SDGs) endorsed by the United Nations, emphasizing the integral part they play in building a sustainable future. The third SDG explicitly calls for ensuring healthy lives and promoting well-being for all at all ages. This goal encompasses a wide range of health objectives, from reducing maternal and child mortality rates, combatting disease epidemics, to improving mental health and well-being. But beyond SDG 3, health is intrinsically linked with almost all the other goals.

When addressing SDG 1, which aims to end poverty, one cannot neglect the social determinants of health. Economic hardship often translates into poor nutrition, inadequate housing, and limited access to health care, leading to a vicious cycle of poverty and poor health. Similarly, achieving SDG 2, ending hunger, also contributes to better health through adequate nutrition, essential for physical and mental development and the prevention of various diseases.

Conversely, the repercussions of climate change, encapsulated in SDG 13, profoundly impact health. Rising global temperatures can lead to increased spread of infectious diseases, compromised food and water supplies, and increased frequency and intensity of extreme weather events, all posing severe health risks. Conversely, the promotion of good health can also mitigate climate change through the reduction of carbon-intensive lifestyles and adoption of healthier, more sustainable behaviors.

SDG 5, advocating for gender equality, also has substantial health implications. Ensuring women's access to sexual and reproductive health services not only improves their health outcomes, but also contributes to societal and economic development. Furthermore, achieving SDG 4, quality education, is also critical for health promotion. Education fosters health literacy, empowering individuals to make informed health decisions, hence improving overall community health.

Lastly, SDG 17 underlines the importance of partnerships for achieving these goals. Multi-sector collaboration is vital to integrate health considerations into all policies and practices. Stakeholders from various sectors, including health, education, agriculture, finance, and urban planning, need to align their efforts in creating sustainable environments that foster health and well-being.

Hence, the relationship between health, well-being, and the SDGs is reciprocal. Improving health and well-being helps in achieving sustainable development, and vice versa. In this context, health and well-being are not just outcomes but are also powerful enablers of sustainable development. For the world to truly thrive, it must recognize and act upon these interconnections.

This article highlights the outbreak of hepatitis among children in the United States and the importance of prevention measures in Africa. It emphasizes the need for Africa to strengthen its healthcare systems to protect children and address infectious diseases.
Elsevier,

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Volume 883-884, 1 November 2022

This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and prenatal genotoxic exposure.
DNA glycosylase Neil3 leads to sex-specific differences in AD. Neil3 increases plaque deposition in female APP/PS1 mice. Neil3 promotes hippocampal neurogenesis and working memory in male APP/PS1 mice. Neil3-dependent DNA damage accumulation does not correlate with AD pathogenesis.
Graphical abstract
This Study supports SDGs 3, 5 and 10, investigating the impact of chemotherapy on the immune system of older women with breast cancer.
This Article supports SDG 3 and 5 by demonstrating the need to better understand the roles that male partners play in encouraging or discouraging care-seeking behaviours during pregnancy and the postpartum period.
Based on current studies, the incidence of Ewing sarcoma (ES) varies significantly by race and ethnicity, with the disease being most common in patients of European ancestry. However, race/ethnicity has generally been self-reported rather than formally evaluated at a population level using DNA evidence. Additionally, mitochondrial dysfunction is a hallmark of ES, yet there have been no reported studies of mitochondrial genetics in ES. Thus, we evaluated both the mitochondrial and nuclear ancestries of 420 pediatric ES patients in the United States using whole-genome sequencing.
An Article in support of SDGs 3, 5, and 10, showing that effective cataract surgical coverage varies widely between countries, increases with greater income level, and is higher in men.
This chapter advances the UN SDG Goal 3: Good Health and Goal 10: Reduced Inequalities by outlining the approaches that can be broadly applied to improve health equity and reduce disparities in perioperative care.
Elsevier,

Biochimica et Biophysica Acta - Molecular Basis of Disease, Volume 1868, 1 November 2022

Infographic showing how sex bias and omission exists in Batten disease research
Batten Disease is a rare disease. This reviews highlights the existing sex bias and omissions in Batten Disease research.
This chapter advances the UN SDG Goal 3: Good Health and Goal 10: Reduced Inequalities by reviewing several patient, hospital, and community-based factors that promote racial and gender disparities in sepsis.

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