Global

This content aligns with Goals 3, 10, and 4 by emphasizing the importance of genomics education for healthcare professionals to provide quality patient care through genomic testing; discussing the disparities in genomics education across different regions, underscoring the need to bridge these gaps and provide equitable access to genomic knowledge and resources; and highlights the need for standardizing and improving the quality of genomics education globally, which aligns with the goal of ensuring inclusive and equitable quality education.

The article investigates the role of CD38, an enzyme implicated in neuroinflammation and cellular senescence, in the context of vascular dementia (VaD). It demonstrates that inhibiting CD38 can mitigate cerebrovascular endothelial cell dysfunction, blood-brain barrier disruption, neuroinflammation, and white matter damage, ultimately alleviating cognitive impairment in a mouse model of VaD. The findings suggest that targeting CD38 may offer a promising therapeutic strategy for addressing the vascular and neurological deficits associated with VaD

A New Interactive Tool Empowers the Public to Search Geo-Targeted Missing Children Alerts Being Distributed Through the ADAM Program. The Dashboard Was Released in Honor of National Missing Children’s Day.

Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel.