Global

This Article supports SDG 3 by showing that short-course tuberculosis preventive treatment is likely to be cost-effective (compared with no tuberculosis preventive treatment) for adult contacts in 15 countries and people living with HIV/AIDS in seven countries, even under conservative cost-effectiveness thresholds.

In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.

This work highlights what we know about climate change impacts that have happened and discuss future directions for research. It supports SDG 13 and 14.

This content aligns with Goal 3: Good Health and Wellbeing by discussing 310 tiglianes reported during 1967–2022, including the mechanisms of action of tiglianes against HIV and discusses the anti-HIV structure–activity relationship of certain tiglianes.