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A non-invasive wearable microwave sensor for Alzheimer's Stage differentiation using realistic 3D human head phantoms

Elsevier,

Results in Engineering, Volume 27, September 2025
This study introduces a new, safe, affordable, and non-invasive device designed to detect and monitor early signs of Alzheimer's disease. Unlike traditional tests like MRI or CT scans, this device uses microwaves to examine the brain.
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Health and wellbeing; Health and population; Technology, Global

Expected Surgical Risk and the Risk of Stroke and Brain Injury After Transcatheter Aortic Valve Replacement: A Patient-Level Pooled Analysis

Elsevier,

Journal of the Society for Cardiovascular Angiography and Interventions, Volume 4, September 2025
The 30-day Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) has been used to risk-stratify patients undergoing transcatheter aortic valve replacement (TAVR). Whether surgical mortality risk predicts stroke and neurocognitive outcomes following TAVR is unknown. We evaluated the association between STS-PROM and clinical outcomes, including stroke, acute brain injury on diffusion-weighted magnetic resonance imaging (DW-MRI), and cognitive decline in patients undergoing TAVR.
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Health and wellbeing, Global

Association Between Thyroid Dysfunction and Alzheimer's Disease: Insights From the U.S. Mortality Database

Elsevier,

Endocrine Practice

Volume 31, Issue 9, Supplement, September 2025, Page S193

 

Evidence from preclinical research suggests that dysfunction in thyroid hormones may increase ?-amyloid levels and tau phosphorylation, 2 hallmark features of Alzheimer's Disease(AD). This study showed a strong association between hypothyroidism and AD mortality.

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Health and wellbeing, Global

Combating Wildlife Trafficking with the Power of Collaboration

LexisNexis Risk Solutions
An image of the front cover of the white paper report featuring an African Elephant

Learn how to help prevent wildlife trafficking by utilising partnerships and data in this joint LexisNexis Risk Solutions and United for Wildlife report.

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Reports

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Wildlife Crime; Biodiversity and ecosystems, Global

RELX Environmental Challenge 2025 shortlist announced

RELX
A youn g child watching anothether child demonstrating the use of a water filter

RELX Environmental Challenge 2025: four shortlisted projects to bring safe water and sanitation to communities around the world

The RELX Environmental Challenge 2025 shortlist features four innovative projects that provide sustainable access to safe water and improved sanitation.  The RELX Environmental Challenge prioritises replicable, scalable, sustainable and innovative solutions. They must also have practical applicability and involve local communities and other key stakeholders.

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Sustainable Water Management; Water and sanitation; Water; Water Resource Management, Global

The cognitive toll of household air pollution: cross–sectional associations between polluting cooking fuel use, cognitive functions and brain MRI in a rural aging population from Karnataka, India

Elsevier,

The Lancet Regional Health - Southeast Asia, Volume 39, August 2025
using neuroimaging, authors try to collect evidence associating polluting cooking fuels with cognitive function impairement in rural aging Indians.
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Health and wellbeing; Health and population, Asia; Global

AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy

Elsevier,

Pharmacological Research, Volume 218, August 2025
This article describes the discovery and characterization of FJMU1887, a novel brain-penetrant small-molecule inhibitor of Galectin-3 (Gal-3) identified through an AI-driven drug discovery platform. FJMU1887 demonstrated potent anti-inflammatory effects, reduced Aβ pathology, and improved cognitive function in Alzheimer's disease mouse models, highlighting its therapeutic potential for the treatment of Alzheimer's disease.
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Health and population; Health and wellbeing, Global

Gray matter and white matter functional connectivity changes induced by rTMS concurrent with cognitive training in Alzheimer's disease

Elsevier,

Brain Research Bulletin, Volume 228, August 2025
This study investigated how repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training affects functional connectivity in both gray matter and white matter in patients with mild to moderate Alzheimer’s disease. Results showed that rTMS modulated activity in key brain regions, particularly within the limbic system, with changes in white matter connectivity correlating with cognitive improvements.
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Health and wellbeing; Health and population, Global

Alzheimer disease: Amyloid peptide controversies and challenges of anti-Aβ immunotherapy

Elsevier,

Journal of Pharmacology and Experimental Therapeutics, Volume 392, August 2025
This review discusses the dual role of amyloid-beta (Aβ) in Alzheimer's disease (AD). While Aβ accumulation is a hallmark of AD pathology, soluble Aβ also plays a neuroprotective role in regulating synaptic plasticity and memory. The review explores the potential of anti-Aβ immunotherapy as a treatment strategy, highlighting the need to balance targeting toxic Aβ species while preserving the physiological functions of Aβ.`
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Health and wellbeing; Health and population, Global

Detoxification and age-related neurodegenerative diseases: Correlation and therapeutic potential

Elsevier,

Pharmacological Research, Volume 218, August 2025
The article provides a comprehensive overview of the role of the endogenous detoxification system in the pathogenesis of age-related neurodegenerative diseases, particularly Alzheimer's disease (AD) and Parkinson's disease (PD). It highlights epidemiological evidence linking environmental toxicant exposure to the onset and progression of these diseases, and discusses how dysfunction of detoxification pathways, including enzymes and transporters, can exacerbate neurodegenerative processes. The article also explores the potential of targeting nuclear receptor signaling pathways, such as the pregnane X receptor (PXR), as a promising therapeutic strategy to restore detoxification capacity and modify disease trajectories.
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Health and population; Health and wellbeing, Global

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