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Despite significant investment, effective treatments for Alzheimer's disease (AD) have been elusive, necessitating improved quality and reproducibility of foundational laboratory evidence; to address this, AD-SOLES, an integrated workflow of automated tools and a publicly accessible interactive dashboard, has been developed to collect, curate, and visualize in vivo experimental evidence, enhancing evidence synthesis, tracking reporting quality, and aiding researchers in locating relevant data.

This study evaluated the behavioral, physiological, and molecular effects of social isolation (SI) in adult zebrafish, and whether the animals recover such changes after their reintroduction to the social environment. The results show that SI altered social behaviors, neural activity, and serotonergic and dopaminergic signaling in zebrafish, but these changes were reversed after the animals were reintroduced to a social context for 6 days.

This study reveals that the estimation of lipids and carotenoid levels could support the early diagnosis or help to understand the pathophysiology of Alzheimer's Disease.

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