Adverse Childhood Experiences and their Life-Long Impact, 2023, Pages 207-242
This content aligns with Goal 3: Good Health as well as Goal 17: Partnership for the goals by reviewing the effects of trauma has on a child including psychological and biological.
In vivo triple transgenic AD mouse model brains and retinas showed hypoxic vessels expressing hypoxyprobe and HIF-1α. In in vitro OGD-treated endothelial cells, HIF-1α upregulated NADPH oxidase (NOX) (i.e., Nox2, Nox4). NLRP1 protein was promoted by OGD, and such effect was blocked by downregulation of Nox4 and HIF-1α. Hypoxic endothelial cells of AD brains and retinas markedly expressed NLRP1, ASC, caspase-1, and interleukin-1β (IL-1β). Chronic hypoxia in microvascular endothelial cells leads to HIF-1α-NLRP1 circuit in AD.
This study observes that oxidative dame in Alzheimer's Diseases is a pathogenic mechanism at the cell-tissue level.
This work highlights what we know about climate change impacts that have happened and discuss future directions for research. It supports SDG 13 and 14.
In an increasingly interconnected world, acts of charity and kindness have profound ramifications that echo beyond borders. Celebrated annually on the 5th of September, the International Day of Charity embodies this spirit. It's a day to rally communities, NGOs, and stakeholders across the globe to amplify the role of charity in building strong, inclusive societies.
I. The Profound Impact of Charity in the Global Landscape
This content aligns with Goal 3: Good Health and Wellbeing by discussing 310 tiglianes reported during 1967–2022, including the mechanisms of action of tiglianes against HIV and discusses the anti-HIV structure–activity relationship of certain tiglianes.
This content aligns with Goal 3: Good Health and Wellbeing by discussing the medical applications and limitations of five US Food and Drug Administration–approved INSTIs for the treatment of HIV/AIDS and preexposure prophylaxis for HIV-1.
The demand for solar energy as a clean way to power human lives is increasing, but solar panels are land-intensive and may compete for space with farms. In this article, the authors examine how agrivoltaics (combining farming and solar technologies) can provide synergistic benefits together rather than in isolation, showing positive benefits in climate mitigation, climate resilience, and land equivalent ratios. This contributes to SDGs 2 (ensuring the promotion of sustainable agriculture), 7 (harnessing sunlight to power society), and 13 (agrivoltaics as a way to combat climate change).
RELX Environmental Challenge 2023: five shortlisted projects to bring safe water and sanitation to communities around the world
In this episode of the "World We Want" podcast, Márcia Balisciano speaks to Dr. Christian Leitz, Managing Director, Secretary of Corporate Culture and Responsibility Committee, and Group Historian and Lead for Long-Term Archives at UBS. During the course of their conversation they cover the challenges to achieving sustainability from all aspects—from historical lessons to providing financial impetus to invest in sustainability.
