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The article discusses the critical role of the mitochondrial contact site and cristae organizing system (MICOS) complex in the pathogenesis of Alzheimer's disease (AD). It highlights how MICOS abnormalities, including subunit dysfunction and interactions with disease-associated proteins, to hallmark AD pathologies such as amyloid-β accumulation, neurofibrillary tangle formation, and neuronal apoptosis. The article suggests that targeting MICOS subunits with pharmacological interventions may provide novel therapeutic insights for AD treatment.
This study investigated the prevalence and impact of auditory agnosia for environmental sounds in individuals with Alzheimer’s disease (AD), finding that over half exhibited signs of this central auditory dysfunction along with a high rate of unrecognized peripheral hearing loss. Although these factors appeared independent and showed limited direct effect on measured quality of life, possibly due to sheltered living environments and lack of patient awareness, they jointly contribute to daily functional decline, highlighting the importance of early hearing assessment and intervention in AD management.
The article discusses the potential of glucagon-like peptide-1 (GLP-1) receptor agonists (GRA) as novel therapeutic agents for neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD). GRA have shown promising effects in modulating neuroinflammation, oxidative stress, mitochondrial and autophagic functions, and protein misfolding in preclinical studies. Clinical trials have demonstrated that GRA like exenatide, liraglutide, and lixisenatide can improve motor deficits in PD and cognitive function in AD patients.

Head and neck cancer (HNC) is the sixth most prevalent cancer worldwide with a poor prognosis when diagnosed at advanced clinical stages. The main risk factors are tobacco consumption and alcohol abuse. The article discusses the use of liquid biopsies as a minimally invasive diagnostic tool for HPV-positive head and neck cancer, as it could improve access to early cancer detection and monitoring.

This study identified the gene PpNLR1 and its promoter variation as key factors conferring green peach aphid (GPA) resistance in peach, regulated by jasmonate-induced transcription factor PpERF109. Additionally, GPA salivary effectors activate the peach immune response through PpNLR1, offering valuable insights for breeding aphid-resistant peach cultivars.

International Day of Play 2026

The International Day of Play is observed each year on June 11. Proclaimed by the United Nations General Assembly in 2024, this day recognizes the essential role of play in human development. It aims to raise awareness, promote policy change, and support efforts to make play accessible for all—especially children—regardless of background or circumstance.

The Significance of Play

The World Health Organization reports that cervical cancer ranks as the eighth most common cancer worldwide and is the ninth leading cause of cancer-related deaths. Cervical cancer is a significant global health challenge, with high incidence and mortality rates, especially in sub-Saharan Africa. While immunotherapy has emerged as a promising strategy, its efficacy is variable among patients. Predictive biomarkers are essential for identifying patients most likely to benefit from immunotherapy.

This chapter supports SDG 2 (Zero Hunger) and SDG 12 (Responsible Consumption and Production) by promoting sustainable agrifood systems and efficient land-use practices that enhance productivity while reducing environmental impact. It also advances SDG 13 (Climate Action) and SDG 15 (Life on Land) through its focus on carbon-neutral agriculture and responsible land management to mitigate climate change and protect terrestrial ecosystems.
This chapter aligns with SDG 7 (Affordable and Clean Energy) and SDG 12 (Responsible Consumption and Production) by promoting the integration of solar energy into agriculture to enhance energy efficiency and resource use. It also supports SDG 2 (Zero Hunger) and SDG 13 (Climate Action) through sustainable farming innovations that improve productivity while reducing environmental impact and greenhouse gas emissions.
Elsevier, One Earth, Volume 8, 20 June 2025
In response to unprecedented global warming in 2023-2024, expert input identified 10 key climate-change research advances with high policy relevance, informing COP29 delegates on critical issues like adaptation, mitigation, and governance of energy-transition minerals.

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