Immunity, Volume 57, 9 April 2024
The activation of the innate immune system and subsequent neuroinflammation are common hallmarks of all neurodegenerative diseases. Castro-Gomez and Heneka review the emerging evidence related to receptors implicated in the activation of innate immunity during neurodegenerative processes. They predominantly focus on the role of microglia, PRRs, and other DAMP-sensing receptors in the pathogenesis of Alzheimer’s disease, tauopathy, Parkinson’s disease, and amyotrophic lateral sclerosis.
Elsevier,
Heliyon, Volume 10, 30 April 2024
The study emphasizes practical application with a user-friendly website, empowering radiologists to predict class probabilities, track disease progression, and visualize patient images in both 2D and 3D formats, contributing significantly to the advancement of early AD detection.
Elsevier,
Frontiers in Neuroendocrinology, Volume 73, April 2024
This review discusses the multifaceted physiological functions of cholecystokinin (CCK), its potential neuroprotective effects in Alzheimer’s and Parkinson’s diseases, and its therapeutic implications, including its impact on memory, neurotransmitters, and neuroprotection mechanisms.
Elsevier,
Neuroscience, Volume 544, 19 April 2024
This study demonstrates that electroacupuncture (EA) improves learning and memory in the 5xFAD mouse model of Alzheimer's disease, likely by enhancing functional connectivity between the hippocampus and neocortex and reducing amyloid-β protein expression and deposition. These findings suggest that EA may positively impact resting-state brain activity and connectivity, contributing to cognitive and motor function improvements in AD.
Elsevier,
Brain Research, Volume 1829, 15 April 2024
Despite diagnostic challenges in differentiating lvPPA and nfvPPA, particularly in advanced cases, this study reveals divergent clinical courses and highlights the importance of assessing emotion processing capacity in dementia diagnosis and monitoring. Utilizing spatiotemporal LME modelling, the research provides valuable insights into the dynamic changes in brain atrophy and behavior, underscoring the need for ongoing evaluation of clinical requirements for patients and families over the disease course.
Elsevier,
Behavioural Brain Research, Volume 463, 12 April 2024
This article discusses the potential therapeutic strategy of enhancing mitophagy through rapamycin treatment to alleviate cognitive impairment in Alzheimer's disease by improving mitochondrial dysfunction and neuronal loss, suggesting a novel mechanism for the neuroprotective effects of rapamycin in AD.
Elsevier,
The Lancet Regional Health - Western Pacific, Volume 45, April 2024
This Article supports SDG 3 by assessing the prevalence of hepatitis B, C, and delta virus in French Polynesia. The findings suggest that the HBV vaccination policy is effective and that HCV and HDV have very low levels of transmission, although some areas did have higher HBV prevalence, warrenting improved vaccine coverage and awareness.
