Nanomedical Drug Delivery for Neurodegenerative Diseases - Chapter 2: Current treads of targeted nanoparticulate carriers for the treatment of Alzheimer’s disease

Nanomedical Drug Delivery for Neurodegenerative Diseases, 2022, Pages 17-39
Davood Gheidaria and Mohammad Bayat

Nano drug delivery systems are promising. By facilitating the influence of drug molecules into the central nervous system and improving their bioavailability, multiple therapeutic groups are targeted. A wide range of nanotechnological treatment methods has been utilized to optimize therapeutics in recent years, including the design, characterization, manufacturing, and applying of drug delivery systems on a nanoscale. These nanotechnologies involve polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, microemulsions, nanoemulsions, carbon nanotubes, metal-based carriers, lipoprotein-based nanoparticles, and liquid crystals. They have been used as drug carriers to increase the solubility, circulation time, and bioavailability of all kinds of drugs. They have also been in the treatment of Alzheimer’s disease. In this chapter, we present drug delivery systems based on nanotechnology to treat Alzheimer’s disease. Any of these instruments holds promise for providing therapeutic equipment to the brain across different prescribed routes, including the intranasal route.