Exploring the therapeutic potential of steroidal alkaloids in managing Alzheimer's disease

Elsevier,

Steroids, Volume 209, September 2024
Steroidal alkaloids from bioactive sources as a potential therapeutic approach to managing Alzheimer’s. It is a review, but I think it shines a really unique light in underexplored, and oft inexpensive, approaches.
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Health and wellbeing, Global

The microtubule-dynamin binding inhibitor peptide PHDP5 rescues spatial learning and memory deficits in Alzheimer's disease model mice

Elsevier,

Brain Research, Volume 1838, 1 September 2024
The study demonstrates that the peptide PHDP5, which inhibits dynamin-MT interaction, can rescue impaired endocytosis and synaptic transmission caused by tau in presynaptic terminals. When administered intranasally to Alzheimer's disease (AD) model mice, PHDP5 significantly improved learning and memory, suggesting its potential as a candidate for human AD therapy.
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Global

A Narrative Review of Alzheimer Dementia in African American and Hispanic Populations: The Health Care Provider's Role

Elsevier,

Journal for Nurse Practitioners, Volume 20, September 2024
Nurse practitioners and other health care providers can play a crucial role in implementing chronic disease management strategies and educating patients who are at risk for AD among African Americans and Hispanics.
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Global

A Systematic Online Living Evidence Summary of experimental Alzheimer's disease research

Elsevier,

Journal of Neuroscience Methods, Volume 409, September 2024
Despite significant investment, effective treatments for Alzheimer's disease (AD) have been elusive, necessitating improved quality and reproducibility of foundational laboratory evidence; to address this, AD-SOLES, an integrated workflow of automated tools and a publicly accessible interactive dashboard, has been developed to collect, curate, and visualize in vivo experimental evidence, enhancing evidence synthesis, tracking reporting quality, and aiding researchers in locating relevant data.
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Health and wellbeing, Global

Neuroprotective action of hordenine against the Aluminium Chloride (AlCl<inf>3</inf>) induced Alzheimer's diseases &amp; associated memory impairment in experimental rats

Elsevier,

Pharmacological Research - Modern Chinese Medicine, Volume 12, September 2024
The study investigates the neuroprotective effects of hordenine against AlCl3-induced Alzheimer’s disease in rats. Results show that hordenine improves memory and cognitive functions, suggesting its potential to reverse oxidative stress and neuroinflammation associated with Alzheimer’s
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Global

How racism plays out in contemporary public health practice (commentary)

Elsevier,

Australian and New Zealand Journal of Public Health, Volume 48, August 2024
This paper seeks to describe and categorise some of the most common behaviours and practices of public health professionals and institutions that introduce or sustain systematic ethnic bias into public health work and thus potentially perpetuate or exacerbate Indigenous inequities in health.
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Oceania

Current Developments in Alzheimer's Disease: Developments in Alzheimer's Disease

Elsevier,

The American Journal of Medicine, Available online 27 August 2024

The present mini-commentary on Alzheimer's disease describes recently revealed pathogenic elements, evolving capabilities for identifying unusually high individual susceptibility and developing tests that predict onset preclinically to allow preventative approaches. Several potential therapies that target cellular signaling and other pathways that are abnormal in Alzheimer's disease are in early clinical trials and will be reviewed briefly.

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North America

Negative impacts of social isolation on behavior and neuronal functions are recovered after short-term social reintroduction in zebrafish

Elsevier,

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 134, 30 August 2024
This study evaluated the behavioral, physiological, and molecular effects of social isolation (SI) in adult zebrafish, and whether the animals recover such changes after their reintroduction to the social environment. The results show that SI altered social behaviors, neural activity, and serotonergic and dopaminergic signaling in zebrafish, but these changes were reversed after the animals were reintroduced to a social context for 6 days.
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Health and population, Global

Prospective comparison of risk factors for firearm suicide and non-firearm suicide in a large population-based cohort of current and former US service members: findings from the Millennium Cohort Study

Elsevier,

The Lancet Regional Health - Americas, Volume 36, August 2024
This paper supports SDG 3 and 8 by examining firearm and non-firearm related suicide in current and former US service members.
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Health and wellbeing, North America

In the Age of AI: Highlights from RELX SDG Inspiration Day 2024

RELX

More than 1100 people came together virtually on 18 June 2024 for the tenth edition of the RELX SDG Inspiration Day: "In the Age of AI: Information to Advance the UN Sustainable Development Goals (SDGs)." The annual online event brings together thought leaders, corporate representatives, students, investors, governments, and NGOs to explore pressing issues, gain practical insight, and inspire action on the United Nations Sustainable Development Goals (SDGs).

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Artificial Intelligence; health technology; Technology; Multi-stakeholder partnerships, Global

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