This Article supports SDG 3 by highlighting that people with disabilities have a two-fold higher mortality rate than people without disabilities in LMICs; a better understanding of this relationship is needed to inform public health planning, policy making, and the allocation of health-care resources to promote healthy longevity for all populations worldwide.
The study introduces a nano-modulator that targets the damaged blood-brain barrier in Alzheimer’s disease. This modulator releases therapeutic agents that reduce amyloid-beta load, alleviate neuroinflammation, and restore neurovascular unit function, showing potential for Alzheimer’s treatment.
This study aimed to assess the correlation between antidiabetic agents and platelet characteristics, hoping to provide a potential mechanism of TZDs neuroprotection in AD
This study investigated VGLUT1 and VGLUT2 expression in the medial temporal lobe and superior temporal gyrus in Alzheimer's disease (AD). The findings reveal region-specific vulnerabilities, with significantly lower VGLUT1 in the dentate gyrus and VGLUT2 in the subiculum and superior temporal gyrus, suggesting potential therapeutic targets that require further exploration.
This article explores the link between alcohol consumption and Alzheimer’s disease (AD), focusing on how serotonergic dysfunction may mediate this relationship. It highlights the roles of neuroinflammation and proteostasis in this process
This review describes recent clinical contributors to ginseng components in clinical tests and introduces emerging evidence that ginseng components could be novel candidates for cognitive improvement in older individuals, as ginseng components improve SMI cognition and exhibits add-on effects when co-administered with early AD dementia drugs. The mechanism behind the beneficial effects of ginseng components and how it improves cognition are presented.
This article discusses age-related changes in species-typical behaviors, such as exploration and grooming, in female 5xFAD mouse model of Alzheimer's disease, suggesting that these behaviors may serve as valuable indicators for modeling the decline in activities of daily living observed in AD patients and assessing the efficacy of potential therapeutics.
Geographic disparities in access to liver transplant for advanced cirrhosis: Time to ring the alarm!
American Journal of Transplantation, Volume 24, May 2024
Nearly 2.4% of global deaths in 2019 were attributed to cirrhosis, which has increased since 2017. Liver transplantation (LT) is accepted as a lifesaving therapy for patients with complications of cirrhosis or hepatocellular cancer, but there are several barriers toward equitable access. This article outlines ways to reduce the disparities
Interesting study on examining the potential molecular mechanism of YGJ using network pharmacology to investigate how Traditional Chinese Medicine disease treatment offers numerous benefits when treating chronic hepatitis.
This Article supports SDG 3 by demonstrating the effectiveness of assisted partner services in Kenya to test the partners of people who inject drugs for HIV and hepatitis C, and support linkage to and engagement in care among those who are positive for either infection.
