Tuberculosis is often reported in people with HIV. In this secondary post-hoc analysis of the A5274 REMEMBER clinical trial, the authors identified that people with HIV and moderate-to-severe anaemia had a higher incidence of TB than those with HIV who did not have anaemia. Addressing two key diseeases listed in SDG 3.3 (HIV and TB), the authors call for close monitoring of people with HIV and anaemia.
This study underscores a novel mechanism(s) underlying HIV-1 Tat-mediated ferroptosis and microglial activation involving miR-204–ACSL4 signaling.
SCFA contribute to the glutamate-glutamine shuttle by acting on glutamine synthetase. Long-term SCFA diet alleviates cognitive and spatial memory defeat in APP/PS1 mice. Long-term SCFA diet reduces Aβ deposition and abnormal phosphorylation of tau. SCFA promote astrocyte-neuron metabolic coupling to reduce oxidative damage.
In this study, a novel reporter substrate named C8CF3-coumarin was synthesized and then characterized, an assay protocol was developed to identify small molecular activators of PLCγ enzymes, and a proof-of-principle high throughput screen was conducted using PLCγ2 and the LOPAC1280 library. These studies showed that C8CF3-coumarin could indeed monitor PLCγ enzyme activity and identify potential small molecule activators from a screen. The identification of such small molecule PLCγ2 activators would be of great utility to the Alzheimer's disease research community by serving as both chemical probes to study the modulation of PLCγ2 and as potential therapeutic agents.
This Article supports SDGs 3 and 13,by presenting evidence on how COVID 19 and climate change have a negative impact on the mental health of youth.
This article highlights the risks of a polluted environment on our health, especially reproductive health and female fertility.
This study engages a broad group of stakeholders to develop a consensus-based research agenda for mental health and psychosocial support (MHPSS) interventions in humanitarian settings.
Explores gender differences in the interactions between people's travel behaviour and their mental health. Suggests policies and strategies that policy-makers and planners could use to promote better mental health specifically among either male or female populations.
This Article supports SDG 3 by examining the relationship between BMI and mental health in a large dataset of adolescents in the UK, finding this relationship to be mediated by happiness with appearance and self esteem. The authors note that greater emphasis should be placed in school cirricula, advertising, and social media on promoting healthy body image and self esteem and reducing weight stigma.
This Article supports SDG 3 by analysing the effect of parental death on subsequent antidepressant use among children and young people, looking at a cohort of 7-24 year olds in Sweden. The study found an increased risk of antidepressant use over the 12 years of follow-up, particularly if the surviving parent has mental health issues. The authors suggest that research and interventions could focus on mental health issues of the child and surviving parent, and the interaction between them.
