Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Volume 883-884, 1 November 2022

This manuscript provides an overview of studies exploring cognitive dysfunction related to DNA damage due to biological ageing process, cancer treatment, adverse environmental or occupational exposures, and prenatal genotoxic exposure.
Graphical abstract
This Study supports SDGs 3, 5 and 10, investigating the impact of chemotherapy on the immune system of older women with breast cancer.
DNA glycosylase Neil3 leads to sex-specific differences in AD. Neil3 increases plaque deposition in female APP/PS1 mice. Neil3 promotes hippocampal neurogenesis and working memory in male APP/PS1 mice. Neil3-dependent DNA damage accumulation does not correlate with AD pathogenesis.
Based on current studies, the incidence of Ewing sarcoma (ES) varies significantly by race and ethnicity, with the disease being most common in patients of European ancestry. However, race/ethnicity has generally been self-reported rather than formally evaluated at a population level using DNA evidence. Additionally, mitochondrial dysfunction is a hallmark of ES, yet there have been no reported studies of mitochondrial genetics in ES. Thus, we evaluated both the mitochondrial and nuclear ancestries of 420 pediatric ES patients in the United States using whole-genome sequencing.
This Article supports SDG 3 and 5 by demonstrating the need to better understand the roles that male partners play in encouraging or discouraging care-seeking behaviours during pregnancy and the postpartum period.

Biochimica et Biophysica Acta - Molecular Basis of Disease, Volume 1868, 1 November 2022

Infographic showing how sex bias and omission exists in Batten disease research
Batten Disease is a rare disease. This reviews highlights the existing sex bias and omissions in Batten Disease research.

The Lancet Planetary Health, Volume 6, October 2022

This Personal View supports SDGs 3 and 13 by reviewing the ways that climate risks affect all aspects of the COVID-19 pandemic, including transmission, perception, and response. The authors highlight the importance of considering climate risks in relation to COVID-19 response measures.
Negative attitudes toward mental illness and treatment are attributed to a lack of or inaccurate mental health knowledge.
Background: There is an urgent need to reduce the burden of depression among older adults in low-income and middle-income countries (LMICs).
This Article supports SDG3 by evaluating whether planned improvements in care equity for hip replacements in England and Wales have been successful.