![Overview of brain [64Cu]-ATSM retention and mitochondrial abnormalities in cells from Huntington's disease carriers, at premanifest and manifest disease stages, and in presymptomatic YAC128 mice.](https://sdgresources.relx.com/sites/default/files/styles/sus_content_listing_image/public/mitochondrial_and_redox_modifications.jpg?itok=PGIl7bso "Overview of brain [64Cu]-ATSM retention and mitochondrial abnormalities in cells from Huntington's disease carriers, at premanifest and manifest disease stages, and in presymptomatic YAC128 mice.")
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD). However, whether these changes occur in early stages of the disease and can be detected in vivo is still unclear. In this article, the authors analysed changes in mitochondrial function and production of reactive oxygen species (ROS) at early stages and with disease progression.
Most disease-gene association methods do not account for gene-gene interactions, even though these play a crucial role in complex, polygenic diseases like Alzheimer's disease (AD).
This Article supports SDG 3 by estimating the impacts of the centralisation of specialist cancer services, focusing on travel time, equity of access, outcomes, and hospital workload. Using rectal cancer surgery centres as an example the authors found increases in travel times but reductions in readmission rates.
The article suggests actions to reduce the negative effect of pandemics on the healthcare workers in future situations, based on lessons learnt from COVID19.
This study assesed how participation in an NSA (Nutrition-Sensitive Agriculture) intervention affected mothers' time allocation to child care. The observation of women-child pairs participating in the intervention and control arms of the NL (Nutrition Links) project did not reveal any differentials in the mothers’ time for care. In summary, this study found that participating in an NSA intervention was not associated with mothers' time for child care or any care received by the child. However, the odds of care provided by another person was associated with being part of the NL-I (Nutrition Links Intervention) group.
This article aligns with the SDG goal 3 of Good health and wellbeing, SDG 10 Reduced inequalities, and SDG 12 Responsible consumption and production by proposing Choosing wisely recommendations to help general practitioners adopt a more rational and cost-effective approach to treating patients with viral hepatitis in Brazil and Latin America.
This content supports the SDG Goal 3: Good health and well-being by exploring the human hepatitis B virus (HBV), family Hepadnaviridae, as a highly infectious virus transmitted by blood and body fluids.
This content supports the SDG Goal 3: Good health and well-being by exploring the important human pathogen HDV.
This content aligns with Goal 10: Reduced Inequalities by exploring how social factors such as access to housing, employment, education, and healthcare contributed to the inequitable impacts of COVID-19.
This article brings us a step closer to bringing clean drinking water to the world by detecting key harmful microbes.
