Healthcare Strategies and Planning for Social Inclusion and Development, 2022, Pages 159-201
Background: Individuals with COPD have increased sensitivity to traffic-related air pollution (TRAP) such as diesel exhaust (DE), but little is known about the acute effects of TRAP on exercise responses in COPD. Research Question: Does exposure before exercise to TRAP (DE titrated to 300 μg/m3 particulate matter < 2.5 μm in diameter [DE300]) show greater adverse effects on exercise endurance, exertional dyspnea, and cardiorespiratory responses to exercise in participants with mild to moderate COPD compared with former smokers with normal spirometry and healthy control participants?