Articles

Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures across the Alzheimer disease continuum

Elsevier, Neuron, Volume 113, 7 May 2025
Changes in β-amyloid (Aβ) and hyperphosphorylated tau (T) in brain and cerebrospinal fluid (CSF) precede Alzheimer's disease (AD) symptoms, making the CSF proteome a potential avenue to understand disease pathophysiology and facilitate reliable diagnostics and therapies. Using the AT framework and a three-stage study design (discovery, replication, and meta-analysis), we identified 2,173 analytes (2,029 unique proteins) dysregulated in AD. Of these, 865 (43%) were previously reported, and 1,164 (57%) are novel.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

Cognitive function and associations with demographic, socioeconomic, health and behavioural factors among older adult men and women in rural Bangladesh: a population-based cross-sectional study

Elsevier,

The Lancet Regional Health - Southeast Asia, Volume 36, May 2025

 Empirical evidence on cognitive function and its association with demographic, socioeconomic, health and behavioural factors among older adults in rural Bangladesh.
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SDG:

Goal 3: Good health and well-being; Goal 10: Reduced inequalities

Tags:

Health and wellbeing, Asia

IUPHAR review: From gut to brain: The role of gut dysbiosis, bacterial amyloids, and metabolic disease in Alzheimer's disease

Elsevier,

Pharmacological Research, Volume 215, May 2025

The article discusses the role of gut dysbiosis, bacterial amyloids, and metabolic diseases in the development and progression of Alzheimer's disease (AD). It highlights the bidirectional relationship between the gut microbiome, inflammation, and metabolic disorders, and how these interconnected pathways contribute to neurodegeneration. The review explores potential therapeutic strategies targeting the gut-brain-metabolic axis to mitigate AD progression.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing; Health and population, Global

Advancements in 3D models for studying human iPSC-microglia: Insights into neurodevelopment and neurological disorders

Elsevier,

hLife, Volume 3, May 2025

The article discusses advancements in using 3D models and human iPSC-derived microglia to study neurodevelopment and neurological disorders, highlighting their potential for understanding brain development, microglial functions, and disease mechanisms. It also explores various models, including organoids and xenotransplantation, and their applications in studying conditions like Alzheimer’s, Parkinson’s, and autism.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

The impact of real-world evidence in implementing and optimizing Alzheimer's disease care

Elsevier,

Med, Volume 6, 9 May 2025

Real-world evidence can supplement clinical trial data to optimize Alzheimer’s disease care by aiding early patient identification and assessing drug effectiveness and safety in everyday use in diverse clinical settings/populations. This information helps inform clinical practice guidelines and supports the development of tools for timely diagnosis and personalized treatment strategies.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

A systematic review of the relationships amongst older adults’ cognitive and motor speech abilities

Elsevier,

Journal of Communication Disorders, Volume 115, 1 May 2025

This systematic review examined the relationship between cognition and motor speech production in healthy older adults and those with mild cognitive impairment, analyzing 22 studies with 747 participants. Findings suggest that cognitive functions, particularly attention and executive abilities, are linked to motor speech performance, though evidence quality varies and gaps remain.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing, Global

The role of semaphorin 3A in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases: A comprehensive review

Elsevier,

Pharmacological Research, Volume 215, May 2025

The article provides a comprehensive review of the role of semaphorin 3A (Sema3A) in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases. It discusses the expression patterns and mechanisms of action of Sema3A in various age-related disorders, including its involvement in oxidative stress, inflammatory responses, apoptosis, and synaptic plasticity.
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SDG:

Goal 3: Good health and well-being

Tags:

Health and wellbeing; Health and population, Global

Chronic pain as a mediator in the falls-frailty association: Evidence from middle-aged and older ethnic minorities in Yunnan, China

Elsevier,

The Journal of Frailty & Aging, 2025, 100050

The article examines the relationship between falls, chronic pain, and frailty among middle-aged and older adults in Yunnan Province, China, with a focus on ethnic minority populations.

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SDG:

Goal 3: Good health and well-being

Tags:

Health and population; Health and wellbeing, Asia

Urban fluxes for free: Estimating urban turbulent surface fluxes from crowdsourced meteorological canyon layer observations

Elsevier,

City and Environment Interactions
Volume 27, August 2025, 100201

This study leverages crowdsourced urban climate data to provide more inclusive and granular insights into urban heat dynamics, addressing gaps in traditional monitoring that often overlook marginalized communities. By harnessing freely available citizen science observations, the method supports the World Population Day theme of "To Leave No One Behind, Count Everyone," enabling more equitable and comprehensive data to inform sustainable urban development and climate resilience.

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SDG:

Goal 13: Climate action

Tags:

Climate Action, Europe

Every two minutes, one woman dies during pregnancy and birth – We are failing mothers

Elsevier,

 

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Despite global progress, maternal mortality remains high, especially in sub-Saharan Africa, highlighting the urgent need for strong leadership, increased investment in well-trained midwives, and equitable, culturally sensitive maternity care to achieve the Sustainable Development Goal of reducing maternal deaths to less than 70 per 100,000 live births by 2030.

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SDG:

Goal 3: Good health and well-being; Goal 5: Gender equality; Goal 10: Reduced inequalities

Tags:

Health and wellbeing; Human rights, Global

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