Elsevier,
IBRO Neuroscience Reports, Volume 16, June 2024
This article summarizes current biomarkers, available treatments, and future therapeutic approaches for Alzheimer's disease, discussing drug targets like Amyloid β, Tau Protein, and various other mechanisms. Additionally, it highlights the historical use of Estradiol, outcomes of trials with antioxidants and omega-3 fatty acids, and ongoing clinical trials, providing a comprehensive overview of the evolving landscape in AD research and treatment.
Elsevier,
Journal of Neuroscience Methods, Volume 406, June 2024
This study presents an optimized method for isolating specific neuronal and glial cell populations and extracellular vesicles (EVs) from postmortem Alzheimer's disease (AD) cortical samples, demonstrating the feasibility of using a single cryopreserved brain sample to obtain RNA-seq and protein-level data, thereby enhancing understanding of neuron/glial interactions and disease progression.
Elsevier,
Molecular and Cellular Neuroscience, Volume 129, June 2024
Neurological disorders affect approximately one billion people worldwide, with significant disability and mortality impacts, and this review explores how Heparan sulfate proteoglycans (HSPGs) promote Tau fibril formation and tangles in Alzheimer's disease, and the potential role of tunnelling nanotubes (TNTs) in the intercellular transport of Tau and Amyloid β proteins, suggesting that HSPGs may influence TNT formation in neurodegenerative conditions.
Elsevier,
Brain Research Bulletin, Volume 212, 15 June 2024
This study reveals that Dl-3-n-butylphthalide (NBP) improves learning deficits and reduces Aβ plaque deposition in Alzheimer's disease (AD) transgenic mice by enhancing microglial activation and phagocytosis of Aβ plaques. The therapeutic effects of NBP are linked to the AGE-RAGE signaling pathway, demonstrating its potential in alleviating cognitive impairment and neuroinflammation in AD.
Elsevier,
Nexus, Volume 1, Issue 3, September 2024
Until now, the absence of data on global building floorspace has impeded the measurement of building carbon intensity (carbon emissions per floorspace) and the identification of ways to achieve carbon neutrality for buildings. For this study, we develop a global building stock model (GLOBUS) to fill that data gap.
Elsevier,
eClinicalMedicine, Volume 72, June 2024
This Article supports SDG3 by evaluating sex and gender disparities in terms of risk factors, treatment uptake/completion, and virological outcomes for hepatitis C, finding differences between men and women in, for example, exposure to different risk factors and likelihood of commencing treatment. More attention is needed in research to these disparities and how they could be addressed
Elsevier,
Quaternary Environments and Humans, Volume 2, Issue 3, June 2024, 100012
The study demonstrates that natural levee evolution in the central Kanto Plain is controlled by river migration and sea-level fluctuations, which are influenced by climate change, providing insights that can inform climate action.
Elsevier, Cell Reports Physical Science, Volume 5, 19 June 2024
This research identifies optimal passive retrofitting methods, such as adding insulation, to enhance the resilience of residential buildings and protect vulnerable communities from the safety risks posed by climate change-driven extreme weather events. By increasing he time a building maintains a safe temperature without external power, this approach helps societies adapt to an already warming world while reducing the energy demand that contributes to further temperature increase.
Elsevier, Cell Reports Physical Science, Volume 5, 19 June 2024
This research demonstrates how the engineering concept of dynamic similitude can be successfully applied to a lab-scale carbon capture column, allowing its performance to accurately predict that of a larger pilot-scale system. Accurately scaling these technologies is a crucial step for the rapid, widespread deployment of carbon management solutions needed to effectively limit global temperature increase and mitigate the severe impacts of climate change.
Elsevier,
The Lancet Oncology, Volume 25, June 2024
This article links to the United Nations Sustainable Development Goals (SDGs) by addressing Goal 3 (Good Health and Well-Being) and Goal 13 (Climate Action), as it highlights the significant greenhouse gas emissions associated with radiotherapy, a critical component of cancer treatment. By proposing strategies to reduce the environmental impact of oncology care through sustainable practices and treatment modifications, the study emphasizes the importance of integrating health care with climate action efforts to promote both patient well-being and environmental sustainability.
