Neurobiology of Brain Disorders - Chapter 19: Alzheimer diseases

Neurobiology of Brain Disorders (Second Edition), Biological Basis of Neurological and Psychiatric Disorders, 2022, Pages 313-336
Alena V. Savonenko, Philip C. Wong, and Tong Li

Over the past several years, significant advances have been made in many areas of Alzheimer's disease (AD) research. Here, we review several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.