World Alzheimer’s Day 2022

An estimated 50 million people around the world currently live with Alzheimer's disease or other dementias, dementia being a collective term for progressive syndromes that affect various expressions of cognitive function, such as memory and emotional expression. Alzheimer’s disease accounts for the majority of cases (50 to 70%, varying by country, based on Alzheimer’s Disease International and World Health Organization figures). For those directly affected and their loved ones, dementia can be a frightening experience, particularly as it is so poorly understood. However there remains little or no understanding of dementia in many, and the stigmatization and misinformation that surrounds dementia remains a global issue.

For 2022 World Alzheimer’s Day the theme Know Dementia, Know Alzheimer’s, organized annually by Alzheimer’s Disease International, focuses on diagnosis, the warning signs of dementia, with a special focus on post-diagnosis support. The aim of this international campaign is to highlight the importance of support for people living with dementia and families following a diagnosis.

Table of contents

Elsevier,

Current Topics in Developmental Biology, Volume 148, January 2022

This book chapter advances SDG 3 and 10 by presenting that (1) some of these depression scales do not correlate, suggesting that they assess different aspects of depression; (2) reports of depression in dementia vary based on depression in dementia scale used; and (3) severe memory impairment may impact the ability to assess depression in the patients using self-reports.
Elsevier,

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by providing therapeutic strategies that can be employed in clinical trials for AD in DS will be discussed as well as their underlying scientific rationale.
Elsevier,

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by providing a brief history of PET imaging and the radiotracers that have had a significant impact for measuring the three signature AD-related neuropathologies related to AD and provides an overview of the research utilizing PET imaging in the DS population
Elsevier,

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by discussing the advantages of performing genetic studies in people with DS, and then discussing the role of reported genes that are known to be associated with AD risk in adults with DS or in the general population. It also discusses how future longitudinal multiomic and imaging study can enhance our understanding of the biology of AD.
Elsevier,

Alzheimer’s Disease: Understanding Biomarkers, Big Data, and Therapy, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by discussing the operational aspects of deep learning solutions for Alzheimer’s disease, including the review of the advantages and limitations of using deep learning, and future directions on the applications of deep learning to Alzheimer’s disease.
Elsevier,

Handbook of Decision Support Systems for Neurological Disorders, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by systematically appraises the concepts and promising benefits of AI technology within healthcare for AD risk prediction across communities, and its possible concerns to be tackled prior to large-scale implementation.
Elsevier,

Alzheimer’s Disease: Understanding Biomarkers, Big Data, and Therapy, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by outlining the applications of big data to Alzheimer’s disease research as well as common methods used to collect and analyze big data. It also explores how big data research could be used to treat, diagnose, and understand Alzheimer’s disease.
Elsevier,

Alzheimer’s Disease: Understanding Biomarkers, Big Data, and Therapy, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by providing evidence that behavioral treatments are more effective than most pharmacological therapies at managing depression in Alzheimer’s disease.
Elsevier,

Sex and Gender Differences in Alzheimer’s Disease, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by stressing that a population health approach and a focus on promoting equity in health and access to care are critical to reducing the risk of AD and other dementias.
Elsevier,

Alzheimer’s Disease: Understanding Biomarkers, Big Data, and Therapy, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by presenting that (1) some of these depression scales do not correlate, suggesting that they assess different aspects of depression; (2) reports of depression in dementia vary based on depression in dementia scale used; and (3) severe memory impairment may impact the ability to assess depression in the patients using self-reports.
Elsevier,

Autophagy in Health and Disease, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by reviewing the extant literature on autophagy in AD and covers recent progress on the molecular mechanisms of NAD+-dependent mitophagy/autophagy regulation and mechanisms underlying the anti-AD potential of NAD+. Further studies to define the NAD+-mitophagy/autophagy axis may shed light on novel therapeutics to treat AD and potentially provide insights into other neurodegenerative diseases.
Elsevier,

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging, Volume , 1 January 2021

This book chapter advances SDG #3 and #10 by reviewing the use of nonhuman primates as a viable model of aging and neurodegeneration research.
Elsevier,

International Review of Neurobiology, Volume 159, January 2021

This book chapter advances SDG #3 and #10 by reviewing deep brain stimulation as a treatment for AD patients, reviewing the recent studies and issues associated with the treatment.
Elsevier,

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1, Volume , 1 January 2020

This book chapter advances SDG #3 and #10 by outlining how both the asymptomatic and symptomatic predementia phases of AD, amyloid positivity using amyloid PET imaging could predict progression to AD dementia. Amyloid PET imaging can identify the status of Aβ deposition in the underlying AD pathophysiology, increase diagnostic certainty, and alter management. This approach could improve the diagnose and management for patients with memory loss or cognitive dysfunction.
Elsevier,

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1, Volume , 1 January 2020

This book chapter advances SDG #3 and #10 by focusing on providing a brief overview of genes associated with sporadic (late-onset) Alzheimer's disease (AD).
Elsevier,

Handbook of Mental Health and Aging, Volume , 1 January 2020

This book chapter advances SDG #3 and #10 by reviewing background on neurocognitive disorders, approaches to diagnosis, and management of several of the more problematic psychiatric complications of dementia. Disorders reviewed include AD, vascular dementia, Lewy body disease, and frontotemporal dementia. Psychiatric symptoms reviewed include apathy, agitation, psychosis, depression, and anxiety.
Elsevier,

Diagnosis and Management in Dementia: The Neuroscience of Dementia, Volume 1, Volume , 1 January 2020

This book chapter advances SDG #3 and #10 by providing an overview of natural AChE inhibitors extracted from plants and their therapeutic potential to treat AD.
Elsevier,

Neuroprotection in Alzheimer's Disease, Volume , 20 January 2017

This book chapter advances SDG #3 and #10 by reviewing neural regeneration–based therapeutic approaches as it represents a highly promising therapeutic strategy for AD, including research that CNTF small-molecule peptide mimetic has demonstrated that neural regeneration–based strategy can also be disease modifying for AD.
Elsevier,

Handbook of Clinical Neurology, Volume 179, January 2021

This book chapter advances SDG #3 and #10 by reviewing the observed epidemiological links between normal and abnormal diurnal and seasonal rhythmicity, cognitive impairment, and ADRD. Then reviewing normal diurnal and seasonal rhythms of brain epigenetic modification and gene expression in model organisms. Finally, reviewing evidence for diurnal and seasonal rhythms of epigenetic modification and gene expression the human brain in aging, Alzheimer's disease, and other brain disorders.
Elsevier,

Handbook of Clinical Neurology, Volume 184, January 2022

This book chapter advances SDG #3 and #10 by reviewing studies that showed treatments with multiple sessions of rTMS can influence cognition in people with neurodegenerative diseases. The chapter also considers novel therapeutic approaches based on the clinical use of rTMS.

Biomarkers in Alzheimer's Disease, 2016, Pages 3-23

This book chapter advances SDG #3 and #10 by providing a brief outline of AD epidemiology, the definition of an AD biomarker, the classification and features of AD, and AD risk factors, followed by a description of the structure and content of each of the following chapters and their focus on specific types of AD biomarkers.

Diagnosis and Treatment of Traumatic Brain Injury, 2022, Pages 27-38

This book chapter advances SDG #3 and #10 by focusing on an emblematic delayed-onset pathology often seen after traumatic brain injury—Alzheimer’s disease—and explain its relationship with chronic traumatic encephalopathy.

Diseases of the Nervous System (Second Edition), 2021, Pages 81-107

This book chapter advances SDG #3 and #10 by introducing the basic foundation of aging, dementia and Alzheimer Disease, including clinical presentation, diagnosis and epidemiology.

Exercise to Prevent and Manage Chronic Disease Across the Lifespan, 2022, Pages 413-421

This book chapter advances SDG #3 and #10 by outlining the pathophysiology associated with Alzheimer’s disease and provide an overview of the impact of exercise programs on cognition, physical functional abilities, behavioral, and psychological symptoms and quality of life.

Genetics, Neurology, Behavior, and Diet in Dementia, The Neuroscience of Dementia, Volume 2, 2020, Pages 833-847

This book chapter advances SDG #3 and #10 by focusing on mouse models of Alzheimer’s disease (AD), especially the 5xFAD line.

Human Caspases and Neuronal Apoptosis in Neurodegenerative Diseases, 2022, Pages 69-151

This book chapter advances SDG #3 and #10 by reviewing the latest developments in the field of clinical diagnosis and pharmacotherapeutics have provided hope to ameliorate the behavioral changes and cognitive disturbances associated with the disease.

Nanomedical Drug Delivery for Neurodegenerative Diseases, 2022, Pages 223-242

This book chapter advances SDG #3 and #10 by highlighting a few newly updated nano drug delivery technologies implemented in Alzheimer’s disease therapies and prospects for the future regarding potential molecular mechanisms of nano drug delivery methods

Neurobiology of Brain Disorders (Second Edition), Biological Basis of Neurological and Psychiatric Disorders, 2022, Pages 313-336

This book chapter advances SDG #3 and #10 by reviewing several key topics that influence our understanding of pathogenic mechanisms and lead to the identification of novel therapeutic strategies. These include the diagnostic spectrum of MCI and AD, genetic risk alleles associated with late-onset AD, structures of gamma-secretase and tau, imaging and fluid biomarkers, the role of microglia and neuroinflammation, and novel animal models of AD.

Neurochemical Aspects of Alzheimer's Disease Risk Factors, Pathogenesis, Biomarkers, and Potential Treatment Strategies, 2017, Pages 47-91

This book chapter advances SDG #3 and #10 by reviewing the risk factors for Alzheimer’s Disease, including normal aging, diet, sedentary lifestyle, sleep disturbances, genes [amyloid precursor protein (APP), presenilin 1 (PSEN1), PSEN2, and APOE], environmental factors, and epigenetic factors.

Plant Extracts in Neurodegenerative Diseases, 2022, Pages 1-15

This book chapter advances SDG #3 and #10 by focusing on polyphenols and flavonoids and their crucial role in decreasing AD symptoms. In addition, it highlights the neuroprotective role of various essential ingredients of plant extracts such as Icariside, Onjisaponin B, Asarones, Liquiritin, Tanshinone IIA (TIIA) and cryptotanshinone (CT), Ginsenoside Rg1, and n-Butylidenephthalide. The efficacy of green nanotechnology are also discussed.
 Share of direct out-of-pocket, informal care, and direct public and private health and LTC insurance costs of dementia in 2018.
Elsevier,

The Lancet Regional Health - Europe, Volume 20, September 2022

An article on dementia and Alzheimer's disease costs, in the context of SDG 3, focusing specifically on the economic costs of care in Europe.
Elsevier,

Experimental Eye Research, Volume 221, August 2022

This research provides the first evidence of AD-related Aβ pathology outside the brain. Lens Aβ can be noninvasively measured in vivo for early AD detection and monitoring.
PPI network analysis of potential targets of trans-UCA involved in spatial memory. (A) PPI network based on STRING database showed 39 potential targets. (B) PPI network based on Cytoscape 3.7.2 software showed 39 potential targets.
Elsevier,

Physiology and Behavior, Volume 252, 1 August 2022

The results of this study suggest that trans-UCA facilitates spatial memory in the Y-maze test and OLR task and may offer therapeutic potential for Alzheimer's disease (AD).
Elsevier,

The Lancet Healthy Longevity, Volume 3, June 2022

An Article on dementia risk factors, in the context of SDG 3, focusing specifically on whether cardiac multimorbidity increases dementia risk.
Screenshot from CIRCA.
Elsevier,

Learning, Culture and Social Interaction, Volume 34, June 2022

People living with dementia are capable of managing novel activities in collaboration with other people living with dementia.
A carer (on the left) gives food to the person with dementia (on the right).
Elsevier,

Journal of Aging Studies, Volume 61, June 2022

This article addresses supporting those with late-stage dementia to maintain quality of life.
Graphical abstract
Elsevier,

Redox Biology, Volume 51, May 2022

This paper reveals effective etiological capabilities of theranostic F-SLOH to target and intervene multiple neuropathological changes in AD mouse models. Therefore, F-SLOH demonstrates tremendous therapeutic potential for treating AD in its early stage.
Elsevier,

The Lancet Healthy Longevity, Volume 3, April 2022

An article on interventions for people with mild dementia, in the context of SDG 3, focusing specifically on the benefits and cost-effectiveness of the Journeying through Dementia intervention in England.
Elsevier, Free Radical Biology and Medicine, Volume 183, April 2022
Genistein is a phytoestrogen that, due to its structural similarity with estrogen, can both mimic and antagonize estrogen effects. Early analysis proved that at high concentrations, genistein inhibits breast cancer cell proliferation, thereby suggesting an anticancer activity. Since then, many discoveries have identified the genistein mechanism of action, including cell cycle arrest, apoptosis induction, as well as angiogenesis, and metastasis inhibition.
Elsevier,

European Journal of Vascular and Endovascular Surgery, Volume 63, April 2022

This article explores whether operations for carotid artery diseases reduce the risk of dementia.
Cross-sectional and longitudinal soluble TREM2 levels in CSF according to estimated years to symptom onset (EYO) in carriers and non-carriers of pathogenic variants.
Elsevier,

The Lancet Neurology, Volume 21, April 2022

An article on Alzheimer's disease progression, in the context of SDG 3, focusing specifically on the dynamics of soluble TREM2 and its association with amyloid and tau markers, neuroimaging features, and cognition.
Elsevier,

The Lancet Regional Health - Europe, Volume 15, April 2022

An article on dementia risk, in the context of SDGs 3 and 10, focusing specifically on the association between ethnicity, socioeconomic deprivation, and dementia risk.
Elsevier,

Frontiers in Neuroendocrinology, Volume 65, April 2022

In vitro and in vivo studies showed that melatonin therapy is effective against AD. The emerging novel melatonin-based therapies are potential treatment options in AD.
Elsevier,

eClinicalMedicine, Volume 45, March 2022

An article on global spending of dementia care, in the context of SDG 3, focusing specifically on modelling global and regional estimates from 2000 to 2019 and expected future scenarios from 2020 to 2050.
Elsevier,

The Lancet Planetary Health, Volume 6, March 2022

An article on air pollution and cognitive decline, in the context of SDGs 3 and 11, focusing specifically on the association between exposure to outdoor air pollutants and cognitive performance.
Elsevier,

The Lancet Healthy Longevity, Volume 3, March 2022

An article on comorbid dementia and depression, in the context of SDG 3, focusing specifically on the effectiveness of music interventions on depressive symptoms for people with dementia.
Change in incidence rate over time in the Alzheimer's disease cohort for health conditions significantly associated with the disease.
Elsevier,

The Lancet Digital Health, Volume 4, March 2022

An article on Alzheimer's disease risk, in the context of SDG 3, focusing specifically on the association between health conditions diagnosed in primary care and incident Alzheimer's disease.
Elsevier,

Journal of Aging Studies, Volume 60, March 2022

This article addresses ways to share the burden of care for those with dementia.
Elsevier,

American Journal of Obstetrics and Gynecology, Volume 226, March 2022

Mental health condition diagnoses were associated with other underlying chronic health conditions and a modestly increased risk of a range of adverse outcomes. The findings suggested that mental health conditions are an important risk factor in adverse maternal outcomes.
Percentage change between 2019 and 2050 in all-age number of individuals with dementia by country.
Elsevier,

The Lancet Public Health, Volume 7, February 2022

An article on the global prevalence of dementia, in the context of SGD 3, focusing specifically on forecasting country-level estimates of dementia prevalence attributable to high BMI, high fasting glucose, and smoking, from 2019 to 2050.
Elsevier,

American Journal of Medicine, Volume , 2022

Higher dietary fiber intake is associated with improved specific components of cognitive function in older adults aged 60 years and older. 
Elsevier,

The Lancet Neurology, Volume 20, November 2021

An article on treatment for Alzheimer's disease, in the context of SDG 3, focusing specifically on whether an angiotensin II receptor antagonist can reduce brain volume loss.
Elsevier,

The Lancet Infectious Diseases, Volume 21, November 2021

An article, in the context of SDG 3, analysing the risk of Alzheimer's disease and other dementias across a range of hospital-treated bacterial and viral infections in two large cohorts.
Elsevier,

Journal of Clinical Densitometry, Volume 24, 1 October 2021

Alzheimer's disease is a strong predictor in survival after hip fracture surgery.
Elsevier,

Behavioural Brain Research, Volume 414, 24 September 2021

Reelin deficiency when combined with AD risk-factors produced consistent impairments in spatial memory tasks. Furthermore, the results further implicate Reelin’s importance in both HF homeostasis and AD pathogenesis.
Elsevier,

EBioMedicine, Volume 71, September 2021

An article on the pathology of Alzheimer's disease, in the context of SDG 3, focusing specifically on the potential use of an anti-cancer drug to modulate cerebrovascular angiogenesis as an alternative therapeutic strategy.
Elsevier,

EClinicalMedicine, Volume 39, September 2021

An article on the detrimental effects of COVID-19 isolation on the cognitive and mental health of people with dementia, in the context of SDGs 3 and 10, highlighting the need for guidance that balances infection control measures with principles of non-maleficence to appropriately care for this patient group.
Schematic representations of the properties and functions of metal chelating agents.
Elsevier,

Journal of Trace Elements in Medicine and Biology, Volume 67, September 2021

Hypotheses for the pathogenesis of Alzheimer’s disease (AD) are described in this paper. The review is intended to be a basic and encyclopedic short insight into metals in AD and discusses the advances in chelation strategies and developments adopted in the treatment of the disease.
Elsevier, The Lancet Healthy Longevity, Volume 2, August 2021
Background: People with dementia die prematurely. Identifying differences in mortality rates between different types of dementia might aid in the development of preventive interventions for the most vulnerable populations. The aim of this study was to compare the difference in mortality rates between individuals without dementia and individuals with various types of dementia.
Elsevier,

The Lancet Healthy Longevity, Volume 2, August 2021

An article on dementia risk factors, in the context of SDG 3, focusing specifically on the association between blood lipid levels and dementia.
Crude DALY rates of non-communicable, communicable, and injury-related neurological disorders in the states of India, 2019.
Elsevier,

The Lancet. Global health, Volume 9, 1 August 2021

An article in support of SDG 3, estimating that 3.69 million people had Alzheimer's disease or other dementias in India in 2019, with prevalence rapidly increasing in those older than 60 years.
Elsevier,

The Lancet Healthy Longevity, Volume 2, July 2021

An article on cognitive assessment in dementia, in the context of SDG 3, focusing specifically on the predictive accuracy of alternative definitions of cognitive impairment.
Elsevier,

The Lancet Healthy Longevity, Volume 2, July 2021

An article on dementia risk factors, in the context of SDG 3, focusing specifically on the association between common infections and dementia.
Elsevier,

The Lancet Healthy Longevity, Volume 2, March 2021

A review on dementia in low-income and middle-income countries, in the context of SDGs 3 and 10, focusing specifically on culturally appropriate treatments and the need for more effectiveness trials on adapted interventions.
Elsevier,

Journal of Transport and Health, Volume 20, March 2021

The article examines the link between physical activity earlier in life and a lower risk of dementia later in life.
Elsevier,

The Lancet Public Health, Volume 6, February 2021

An article on the long-term risk of dementia, in the context of SDG 3, focusing specifically on the association between dementia onset and reduced participation in cognitive and social activities.
Elsevier, The Lancet Healthy Longevity, Volume 1, December 2020
Background: Circadian disturbances are commonly seen in people with Alzheimer's disease and have been reported in individuals without symptoms of dementia but with Alzheimer's pathology. We aimed to assess the temporal relationship between circadian disturbances and Alzheimer's progression. Methods: We did a prospective cohort study of 1401 healthy older adults (aged >59 years) enrolled in the Rush Memory and Aging Project (Rush University Medical Center, Chicago, IL, USA) who had been followed up for up to 15 years.
Elsevier,

The Lancet Public Health, Volume 5, December 2020

An article on the prevalence, risk factors, and management of dementia in older adults in China, in the context of SDG 3, highlighting the need for the development of a prevention strategy and optimising clinical management.
Non-linear associations between number of individual components of the frailty phenotype and dementia incidence
Elsevier,

The Lancet Healthy Longevity, Volume 1, November 2020

An article on dementia incidence, in the context of SDG 3, focusing specifically on the association between physical frailty and all-cause dementia in the UK.
Elsevier,

The Lancet, Volume 396, 8 - 14 August 2020

A Commission on dementia prevention, intervention, and care, in the context of SDG 3, focusing specifically on individual-level and policy-level interventions for modifying risk factors to prevent or delay onset, tackling inequalities, providing holistic post-diagnostic care, managing neuropsychiatric symptoms, and caring for family carers.
Elsevier,

Redox Biology, Volume 34, July 2020

Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD) are distinct clinical entities; however, the aggregation of key neuronal proteins, presumably leading to neuronal demise appears to represent a common mechanism. It has become evident that advanced glycation end products (AGEs) trigger the accumulation of such modified proteins, which eventually contributes to the pathological aspect of NDDs. Increased levels of AGEs are found in amyloid plaques in AD brains and in both advanced and early PD (incidental Lewy body disease). The molecular mechanisms by which AGE dependent modifications may modulate the susceptibility towards NDDs, however, remain enigmatic and it is unclear whether AGEs may serve as biomarker of NDD. This study detected differential associations between NDD, sex and oxidative stress markers.
 Imaging signature of Alzheimer's disease in adults with Down syndrome for brain structure, glucose metabolism, and amyloid β deposition.
Elsevier,

The Lancet, Volume 395, 27 June - 3 July 2020

An article on the natural history of Alzheimer's disease in adults with Down syndrome, in the context of SDGs 3 and 10, focusing specifically on the order and timing of biomarker changes in this population.
Discrimination accuracy of models by study site.
Elsevier,

The Lancet Global Health, Volume 8, April 2020

An article in support of SDG 3, assessing whether and to what extent existing dementia prevention models developed in high-income countries can be extrapolated to low-income and middle-income countries, where dementia risk prediction research is almost non-existent.
Elsevier,

American Journal of Medicine, Volume 134, August 2021

Clinicians increasingly face the challenge of caring for patients who say that they would prefer death to life with advanced dementia.
The research and co-design phases of the MinD project.
Elsevier,

Journal of Aging Studies, Volume 60, March 2022

An investigation demonstrating a way to support the well-being of people with dementia.
Elsevier,

Experimental Eye Research, Volume 221, August 2022

This research provides the first evidence of AD-related Aβ pathology outside the brain. Lens Aβ can be noninvasively measured in vivo for early AD detection and monitoring.
Elsevier,

The Lancet Healthy Longevity, Volume 3, June 2022

An Article on dementia risk factors, in the context of SDG 3, focusing specifically on whether cardiac multimorbidity increases dementia risk.
Graphical abstract
Elsevier,

Free Radical Biology and Medicine, Volume 162, January 2021

Proteasome function is impaired in Alzheimer's disease (AD). Proteasome activation is followed by a decrease in amyloid-beta (Aβ) load. A reduced amount of Aβ correlates with significantly improved behavior and frailty level. Proteasome activation represents a promising intervention for alleviating AD pathology.
Alzheimer’s Disease, the dark side of the mitochondria.
Elsevier,

Mitochondrion, Volume 64, May 2022

Alzheimer's disease (AD) is a leading neurodegenerative pathology associated with aging worldwide. It is estimated that AD prevalence will increase from 5.8 million people today to 13.8 million by 2050 in the United States alone. AD effects in the brain are well known; however, there is still a lack of knowledge about the cellular mechanisms behind the origin of AD. It is known that AD induces cellular stress affecting the energy metabolism in brain cells.

Effects of aging on nitric oxide bioavailability, physiological function, and exercise performance.
Elsevier,

Nitric Oxide - Biology and Chemistry, Volume 125-126, 1 August 2022

Worldwide, individuals are living longer. This population aging is associated with an anticipated increase in the burden of the leading causes of death in modern societies — chronic, degenerative diseases such as cardiovascular, kidney and Alzheimer's disease — which is largely driven by age-related declines in physiological function. Engaging in healthy lifestyle practices that preserve physiological function with age has important implications for reducing the risk of morbidity and mortality and preserving healthspan — the period of an individual's life when one is generally healthy and devoid of serious chronic disorders. In this regard, regular exercise and physical activity are considered key “first line” strategies for healthy aging.
Elsevier,

SLAS Discovery, Volume 26, March 2021

Tauopathies are neurological disorders characterized by intracellular tau deposits forming neurofibrillary tangles, neuropil threads, or other disease-specific aggregates composed of the protein tau. Tauopathy disorders include frontotemporal lobar degeneration, corticobasal degeneration, Pick’s disease, and the largest cause of dementia, Alzheimer’s disease. The lack of disease-modifying therapeutic strategies to address tauopathies remains a critical unmet need in dementia care. Thus, novel broad-spectrum tau-targeted therapeutics could have a profound impact in multiple tauopathy disorders, including Alzheimer’s disease. Here we have designed a drug discovery paradigm to identify inhibitors of the pathological tau-enabling protein, MSUT2. We previously showed that activity of the RNA-binding protein MSUT2 drives tauopathy, including tau-mediated neurodegeneration and cognitive dysfunction, in mouse models. Thus, we hypothesized that MSUT2 inhibitors could be therapeutic for tauopathy disorders.
Elsevier,

Biomarkers in Neuropsychiatry, Volume 1, December 2019

This paper summarizes the literature findings regarding the most widely and consistently accepted diagnostic biomarkers of the f Alzheimer's disease (AD) continuum according to ATN classification. It examined their diagnostic accuracy for AD in comparison with healthy elderly controls and those with other types of dementias and also discussed their limitations and the reasons behind their limited use in routine clinical settings. Moreover, new research avenues in developing biomarkers were also presented.
Elsevier,

Biomarkers in Neuropsychiatry, Volume 5, December 2021

This review article examines the various types of diagnostic biomarkers which are used in the early detection of Alzheimer’s disease and summerizes the A/T/N classification system for Alzheimer’s biomarkers and its use in the biomarker-based diagnosis of Alzheimer’s disease. Furthermore it reviews the use of structural MRI, 18F-FDG PET, Amyloid PET, Tau PET, cerebrospinal fluid biomarkers, and the emerging role of plasma biomarkers in the diagnosis of Alzheimer’s disease. In doing so the authors discuss each biomarkers correlation with pathologic findings, ability to distinguish Alzheimer’s disease from healthy aging, ability to distinguish Alzheimer’s disease from other neurodegenerative diseases, role in A/T/N classification system, and limitations of each biomarker.
Elsevier,

Biomarkers in Neuropsychiatry, Volume 3, December 2020

Change point analysis can reveal when a biomarker starts to diverge from the pattern of normal aging. This paper analyzes several biomarkers from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to estimate the sequence and timing of their change points relative to a subsequent clinical diagnosis of mild cognitive impairment (MCI) in subjects initially considered cognitively normal (CN).